Sikuler E, Groszmann R J
Experientia. 1985 Oct 15;41(10):1323-4. doi: 10.1007/BF01952076.
Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413 +/- 26 vs 318 +/- 23 ml X min-1 X kg-1; p less than 0.05) and portal venous inflow (9.61 +/- 1.29 vs 6.33 +/- 0.36 ml X min-1 X 100 g b.wt-1; p less than 0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.
在联体生活和门静脉高压大鼠模型中进行了内脏和全身血流动力学研究。将一只门静脉高压大鼠和一只正常大鼠手术并排联体。在所有门静脉高压大鼠中均发现高动力循环，其特征为心脏指数增加（413±26 对 318±23 ml·min⁻¹·kg⁻¹；p<0.05）和门静脉血流增加（9.61±1.29 对 6.33±0.36 ml·min⁻¹·100 g 体重⁻¹；p<0.05），而在正常联体伙伴中未发现。这些结果不支持存在可转移的体液因子介导慢性门静脉高压的高动力循环状态。
