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钙可加速模拟胆汁中胆固醇的相变。

Calcium accelerates cholesterol phase transitions in analog bile.

作者信息

Berenson M M, Cardinal J R

出版信息

Experientia. 1985 Oct 15;41(10):1328-30. doi: 10.1007/BF01952079.

DOI:10.1007/BF01952079
PMID:4043315
Abstract

Analog bile supersaturated with cholesterol was constituted, filtered and divided into equal portions containing no calcium or calcium, 2.5-15 mM. Aliquots were removed over the next 48 h and filtrates analyzed for cholesterol, bile acid and lecithin. Calcium accelerated cholesterol loss from solution in a dose-related fashion.

摘要

制备了胆固醇过饱和的模拟胆汁,过滤后分成不含钙或含钙(2.5 - 15 mM)的等份。在接下来的48小时内取出等分试样,对滤液进行胆固醇、胆汁酸和卵磷脂分析。钙以剂量相关的方式加速了溶液中胆固醇的损失。

相似文献

1
Calcium accelerates cholesterol phase transitions in analog bile.钙可加速模拟胆汁中胆固醇的相变。
Experientia. 1985 Oct 15;41(10):1328-30. doi: 10.1007/BF01952079.
2
Prolonged secretion of lithogenic bile after cholecystectomy.胆囊切除术后致石性胆汁的长期分泌。
Ann Surg. 1975 Aug;182(2):150-3. doi: 10.1097/00000658-197508000-00012.
3
[A study on the size of molecular aggregates formed by a bile acid-lecithin-cholesterol model solution].[胆汁酸-卵磷脂-胆固醇模型溶液形成的分子聚集体大小的研究]
Nihon Shokakibyo Gakkai Zasshi. 1987 Jan;84(1):129.
4
Biliary excretion of lecithin and cholesterol in the dog.狗体内卵磷脂和胆固醇的胆汁排泄
J Clin Invest. 1972 Jun;51(6):1337-50. doi: 10.1172/JCI106930.
5
Dissolution kinetics of cholesterol in simulated bile I: Influence of bile acid type and concentration, bile acid-lecithin ration, and added electrolyte.胆固醇在模拟胆汁中的溶解动力学I:胆汁酸类型与浓度、胆汁酸-卵磷脂比例及添加电解质的影响
J Pharm Sci. 1977 Aug;66(8):1094-101. doi: 10.1002/jps.2600660811.
6
Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability.胆汁盐对鞘磷脂与胆固醇之间分子相互作用的影响:与胆汁形成和稳定性的相关性。
Biochim Biophys Acta. 1997 Apr 21;1345(3):269-82. doi: 10.1016/s0005-2760(97)00002-7.
7
Cholesterol enhances membrane-damaging properties of model bile by increasing the intervesicular-intermixed micellar concentration of hydrophobic bile salts.胆固醇通过增加疏水性胆盐的囊泡间混合微团浓度来增强模型胆汁的膜损伤特性。
J Surg Res. 1999 Jun 1;84(1):112-9. doi: 10.1006/jsre.1999.5625.
8
Separation and quantitation of cholesterol "carriers" in bile.胆汁中胆固醇“载体”的分离与定量
Hepatology. 1990 Sep;12(3 Pt 2):94S-104S; discussion 104S-105S.
9
The physicochemical basis of cholesterol gallstone formation in man.人类胆固醇胆结石形成的物理化学基础。
J Clin Invest. 1968 May;47(5):1043-52. doi: 10.1172/JCI105794.
10
Acceleration of cholesterol phase transitions in analog bile by chlorpromazine, pentobarbital and ethinyl estradiol.氯丙嗪、戊巴比妥和炔雌醇对模拟胆汁中胆固醇相变的加速作用。
Res Commun Chem Pathol Pharmacol. 1984 Apr;44(1):113-22.

本文引用的文献

1
Cholesterol crystals and the formation of cholesterol gallstones.胆固醇晶体与胆固醇胆结石的形成
N Engl J Med. 1980 Jun 5;302(23):1274-7. doi: 10.1056/NEJM198006053022302.
2
Interactions between ionized calcium and sodium taurocholate: bile salts are important buffers for prevention of calcium-containing gallstones.离子钙与牛磺胆酸钠之间的相互作用:胆汁盐是预防含钙胆结石的重要缓冲剂。
Gastroenterology. 1982 Nov;83(5):1079-89.
3
Nucleation of cholesterol monohydrate crystals from hepatic and gall-bladder bile of patients with cholesterol gall stones.
胆固醇胆结石患者肝胆汁和胆囊胆汁中胆固醇一水合物晶体的成核作用。
Gut. 1983 Sep;24(9):836-44. doi: 10.1136/gut.24.9.836.
4
Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol gallstones.胆固醇结石患者胆囊胆汁中存在强效成核因子的证据。
Gastroenterology. 1983 Oct;85(4):801-7.
5
The role of calcium in the pathogenesis of gallstones: Ca++ electrode studies of model bile salt solutions and other biologic systems. With an hypothesis on structural requirements for Ca++ binding to proteins and bile acids.钙在胆结石发病机制中的作用:对模型胆盐溶液及其他生物系统的钙离子电极研究。并提出关于钙离子与蛋白质和胆汁酸结合的结构要求的假说。
Hepatology. 1984 Sep-Oct;4(5 Suppl):228S-243S.
6
Bile salt structure and phase equilibria in aqueous bile salt and bile salt-lecithin systems.胆盐在胆盐水溶液及胆盐-卵磷脂体系中的结构与相平衡。
Hepatology. 1984 Sep-Oct;4(5 Suppl):138S-142S. doi: 10.1002/hep.1840040824.
7
Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile.载脂蛋白在过饱和模型胆汁中对胆固醇晶体形成的抑制作用。
Science. 1984 Aug 3;225(4661):514-6. doi: 10.1126/science.6429856.
8
Structural aspects of bile salt-lecithin mixed micelles.胆盐 - 卵磷脂混合微团的结构方面
Hepatology. 1984 Sep-Oct;4(5 Suppl):134S-137S. doi: 10.1002/hep.1840040823.
9
Bile composition: Sweden versus Japan. Its possible significance in the difference in gallstone incidence.胆汁成分:瑞典与日本的对比。其在胆结石发病率差异方面的潜在意义。
Am J Surg. 1971 Jul;122(1):8-12. doi: 10.1016/0002-9610(71)90337-0.
10
Cholesterol solubility in model bile systems: implications in cholelithiasis.胆固醇在模拟胆汁系统中的溶解度:对胆石症的影响。
J Pharm Sci. 1974 Mar;63(3):327-32. doi: 10.1002/jps.2600630303.