Kohli Arjun Singh, Sanyal Somali, Kaushal Radhey Shyam, Dwivedi Manish
Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus, Gomtinagar Ext., Lucknow, 226028, India.
Department of Biotechnology, Parul University, Gujrat, India.
Curr Genomics. 2025;26(3):175-190. doi: 10.2174/0113892029319505240821063238. Epub 2024 Aug 30.
The development of a cancer vaccine comes with its complications and designing and developing a vaccine against foreign invaders such as bacterial and viral particles is not as complex and multi-faceted as the preparation of immunotherapy for host-infected cells which resemble our own body cells. The entire research and development framework of designing a vaccine for cancerous cells lies entirely on the remarkable aspect of notifying specific interactions and acclimatising the immune system. This review aims to compile the several fronts research-based methodology applies to in terms of developing a therapeutic, preventive or personalised vaccine for cancer. The approach lays focus on the identification and selection of targets for vaccine development which have come to light as immune biomarkers. Furthemore, significant aspects of personalised and precision vaccines and the fine line that runs between these approaches have also been discussed.
癌症疫苗的研发存在其复杂性，而且设计和开发针对诸如细菌和病毒颗粒等外来入侵者的疫苗，不像为类似于我们自身身体细胞的宿主感染细胞制备免疫疗法那样复杂且多方面。为癌细胞设计疫苗的整个研发框架完全在于识别特定相互作用并使免疫系统适应这一显著方面。本综述旨在汇总在开发用于癌症的治疗性、预防性或个性化疫苗方面所应用的基于多方面研究的方法。该方法着重于识别和选择已作为免疫生物标志物而出现的疫苗开发靶点。此外，还讨论了个性化和精准疫苗的重要方面以及这些方法之间的细微差别。
