The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, United States.
Cancer Immunotherapies Laboratory, Mater Research Institute, University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Adv Immunol. 2020;148:49-91. doi: 10.1016/bs.ai.2020.10.002. Epub 2020 Nov 1.
Dendritic cells are a specialized subset of hematopoietic cells essential for mounting immunity against tumors and infectious disease as well as inducing tolerance for maintenance of homeostasis. DCs are equipped with number of immunoregulatory or stimulatory molecules that interact with other leukocytes to modulate their functions. Recent advances in DC biology identified a specific role for the conventional dendritic cell type 1 (cDC1) in eliciting cytotoxic CD8+ T cells essential for clearance of tumors and infected cells. The critical role of this subset in eliciting immune responses or inducing tolerance has largely been defined in mice whereas the biology of human cDC1 is poorly characterized owing to their extremely low frequency in tissues. A detailed characterization of the functions of many immunoregulatory and stimulatory molecules expressed by human cDC1 is critical for understanding their biology to exploit this subset for designing novel therapeutic modalities against cancer, infectious disease and autoimmune disorders.
树突状细胞是造血细胞的一个特殊亚群，对于针对肿瘤和传染病的免疫以及诱导维持体内平衡的耐受性至关重要。DC 配备了许多免疫调节或刺激分子，这些分子与其他白细胞相互作用以调节其功能。DC 生物学的最新进展确定了传统树突状细胞 1 型 (cDC1) 在引发细胞毒性 CD8+T 细胞中的特定作用，这些细胞对于清除肿瘤和感染细胞至关重要。该亚群在引发免疫反应或诱导耐受性方面的关键作用在很大程度上已在小鼠中得到定义，而由于其在组织中的极低频率，人类 cDC1 的生物学特征尚不清楚。对人类 cDC1 表达的许多免疫调节和刺激分子的功能进行详细表征对于理解其生物学特性至关重要，以便利用该亚群设计针对癌症、传染病和自身免疫性疾病的新型治疗方法。
