Hou Dan, Zhao Jiatong, Guo Mingshi, Zhang Xinran, Yu Shuiqing, Li Jiayue, Forouzanfar Tymour, Zhang Qing, Pathak Janak L
School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.
Department of Oral and Maxillofacial Surgery/Oral Pathology, UMC and Academic Centre for Dentistry Amsterdam (ACTA), Cancer Center Amsterdam, Vrije Universiteit Amsterdam, Amsterdam, 1081 HZ, The Netherlands.
Probiotics Antimicrob Proteins. 2025 May 28. doi: 10.1007/s12602-025-10578-3.
This study explores the current status, research hotspots, and emerging trends in AMP-induced cell death through bibliometric and data-driven visual analysis. The findings aim to provide researchers and clinical professionals with new insights and potential research directions. A total of 1,897 articles and reviews published between 2006 and 2024 were retrieved from the Web of Science Core Collection. Bibliometric and visual analyses were conducted using CiteSpace, VOSviewer, Scimago Graphica, Origin 2022, and WordClouds. The analysis focused on publication trends, contributing institutions, journals, authors, cited references, and keywords. China contributed the largest share of publications (28.15%). The Chinese Academy of Sciences emerged as the most collaborative institution, demonstrating the highest centrality. The author with the highest composite index was Chen, Jyh-Yih (2,985.27). Recent research hotspots have centered on elucidating the mechanisms of AMP-induced cell death and exploring the potential applications of AMPs in cancer therapy. Keywords such as anticancer peptides, mechanism, design, and antibiotic resistance currently dominate the field, reflecting its evolving focus. Research on the application of AMPs in cancer treatment is gaining momentum. The forefront of this field involves modifying and designing AMPs to address antibiotic-resistant bacterial infections and advance cancer therapeutics. However, further investigation is needed to uncover the specific molecular mechanisms underlying AMP-induced cell death, including necrosis, pyroptosis, and ferroptosis.
本研究通过文献计量和数据驱动的可视化分析，探讨了抗菌肽（AMP）诱导细胞死亡的现状、研究热点和新趋势。研究结果旨在为研究人员和临床专业人员提供新的见解和潜在的研究方向。从科学网核心合集检索了2006年至2024年间发表的1897篇文章和综述。使用CiteSpace、VOSviewer、Scimago Graphica、Origin 2022和WordClouds进行文献计量和可视化分析。分析重点关注发表趋势、贡献机构、期刊、作者、被引参考文献和关键词。中国的出版物占比最大（28.15%）。中国科学院是合作最多的机构，具有最高的中心性。综合指数最高的作者是陈义益（2985.27）。最近的研究热点集中在阐明抗菌肽诱导细胞死亡的机制以及探索抗菌肽在癌症治疗中的潜在应用。目前，抗癌肽、机制、设计和抗生素耐药性等关键词主导着该领域，反映了其不断变化的重点。抗菌肽在癌症治疗中的应用研究正在兴起。该领域的前沿包括对抗菌肽进行修饰和设计，以解决抗生素耐药性细菌感染问题并推进癌症治疗。然而，需要进一步研究以揭示抗菌肽诱导细胞死亡的具体分子机制，包括坏死、焦亡和铁死亡。
