Liu Tingwei, Yin Zhi, Tao Meng, Meng Xiaoqi, Zhong Hui, Xu Yang, Sun Xiulan
Department of Dermatology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Department of Dermatology, Zigong Fourth People's Hospital, Zigong, China.
Ann Med. 2025 Dec;57(1):2512123. doi: 10.1080/07853890.2025.2512123. Epub 2025 May 28.
It remains controversial whether neurogenic rosacea (NR) is a distinctive subtype of rosacea, and no study has been conducted on the Chinese population. We compared the clinical characteristics of patients with NR and erythematotelangiectatic rosacea (ETR) and explored whether NR can be considered a distinctive rosacea subtype.
Nineteen patients with NR and 73 with ETR were enrolled. A questionnaire survey combined with electronic medical records and VISIA digital images was used to collect information on patients' baseline demographic and clinical characteristics.
The patients in the NR group reported less facial pruritus (36.8%) and dry skin (31.6%) than those in the ETR group ( < .05). The incidence and scores of flushing symptom-related evaluation indices in the NR group were higher than those in the ETR group ( < .05). The efficacy of drug treatment in the NR group (38.9%) was lower than that in the ETR group (85.5%, < .05).
There were few differences between ETR and NR in the Chinese population, with the exception of dryness and itching, though there was only a small sample size of NR in this study. NR may be referred to as ETR in patients with refractory erythema.
神经源性酒渣鼻（NR）是否为酒渣鼻的一种独特亚型仍存在争议，且尚未有针对中国人群的研究。我们比较了NR患者和红斑毛细血管扩张型酒渣鼻（ETR）患者的临床特征，并探讨了NR是否可被视为一种独特的酒渣鼻亚型。
纳入19例NR患者和73例ETR患者。采用问卷调查结合电子病历及VISIA数字图像的方式收集患者的基线人口统计学和临床特征信息。
NR组患者面部瘙痒（36.8%）和皮肤干燥（31.6%）的发生率低于ETR组（P<0.05）。NR组潮红症状相关评估指标的发生率和评分高于ETR组（P<0.05）。NR组药物治疗有效率（38.9%）低于ETR组（85.5%，P<0.05）。
在中国人群中，ETR和NR之间除干燥和瘙痒外差异不大，尽管本研究中NR的样本量较小。对于难治性红斑患者，NR可能被归为ETR。
