Yang Fengjuan, Wang Lian, Shucheng Huidi, Jiang Xian
Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.
J Cosmet Dermatol. 2023 Mar;22(3):949-957. doi: 10.1111/jocd.15470. Epub 2022 Nov 27.
Aging remains a common influencing factor for many diseases. Previous studies have shown that age is significantly associated with rosacea among female cases and that the incidence of rosacea increases with age. However, previous studies did not specifically analyze the clinical characteristics of different age groups.
This study aimed to analyze and compare the clinical characteristics of female patients of rosacea among different age groups.
We conducted a retrospective study of 840 female rosacea subjects and compared cutaneous features, aggravating factors, systemic diseases, and psychological states across age groups. The patients were divided into three groups according to their age at diagnosis: ≤30 years，31-44 years，and ≥45 years.
In our study, the mean age of subjects was 35.9 ± 10.23 years. The common symptoms included telangiectasia (82.6%), persistent erythema (82.0%), burning/stinging sensation (89.3%), dry sensation (74.0%), and pruritis (41.9%). Hot temperature (89.9%), emotional changes (67.3%), spicy food (55.6%), and sun exposure (50.7%) were the common aggravating factors. Some patients had comorbidities of systemic disorders (20.4%). Of the patients, 48.8% presented with anxiety and 35.2% with depression. The clinical characteristics were found to be significantly different among the different age groups. Middle-aged and older patients (≥45 years) were more likely to have more serious persistent erythema and telangiectasia. And these patients were relatively less affected by some of the influencing factors and had more systemic diseases of the digestive system, endocrine metabolic system, and cardiovascular system (p < 0.05).
We revealed the impact of age on the characteristics of rosacea, which indicated that the clinical features of rosacea are more complex and more difficult to treat in females over the age of 45.
衰老仍是许多疾病的常见影响因素。既往研究表明，年龄在女性酒渣鼻病例中与酒渣鼻显著相关，且酒渣鼻发病率随年龄增长而增加。然而，既往研究未对不同年龄组的临床特征进行具体分析。
本研究旨在分析和比较不同年龄组女性酒渣鼻患者的临床特征。
我们对840例女性酒渣鼻患者进行了一项回顾性研究，并比较了各年龄组的皮肤特征、加重因素、全身性疾病和心理状态。根据诊断时的年龄将患者分为三组：≤30岁、31 - 44岁和≥45岁。
在我们的研究中，受试者的平均年龄为35.9±10.23岁。常见症状包括毛细血管扩张（82.6%）、持续性红斑（82.0%）、灼痛/刺痛感（89.3%）、干燥感（74.0%）和瘙痒（41.9%）。高温（89.9%）、情绪变化（67.3%）、辛辣食物（55.6%）和日晒（50.7%）是常见的加重因素。部分患者有全身性疾病合并症（20.4%）。患者中，48.8%表现为焦虑，35.2%表现为抑郁状态。发现不同年龄组的临床特征存在显著差异。中年及老年患者（≥45岁）更易出现更严重的持续性红斑和毛细血管扩张。而且这些患者受某些影响因素的影响相对较小，有更多消化系统、内分泌代谢系统和心血管系统的全身性疾病（p<0.05）。
我们揭示了年龄对酒渣鼻特征的影响，这表明45岁以上女性酒渣鼻的临床特征更复杂且更难治疗。
