Yamanishi Y, Nosaka Y, Kawasaki H, Hirayama C, Ikawa S
Gastroenterol Jpn. 1985 Jun;20(3):246-51. doi: 10.1007/BF02774711.
Serum levels of squalene, cholesterol and bile acid were measured before and after short-term prednisolone administration in patients with chronic active hepatitis. Comparison with normal controls indicated that serum bile acid levels were increased significantly (p less than 0.01) in patients with chronic active hepatitis, but serum levels of squalene and cholesterol did not differ significantly between the two groups. After short-term prednisolone treatment, serum levels of squalene and cholesterol were increased significantly (p less than 0.01) as compared with the pretreatment level. On the other hand, while serum fasting bile acid levels were found to be increased significantly (p less than 0.01), serum clearance after oral administration of ursodeoxycholic acid improved significantly (p less than 0.05) after treatment. These results indicated that short-term prednisolone treatment increases sterol metabolism in the liver in patients with chronic active hepatitis, resulting from an increase in hepatic clearance of bile acids.
在慢性活动性肝炎患者中，测定了短期给予泼尼松龙前后血清中角鲨烯、胆固醇和胆汁酸的水平。与正常对照组相比，慢性活动性肝炎患者血清胆汁酸水平显著升高（p<0.01），但两组间血清角鲨烯和胆固醇水平无显著差异。短期泼尼松龙治疗后，与治疗前水平相比，血清角鲨烯和胆固醇水平显著升高（p<0.01）。另一方面，虽然空腹血清胆汁酸水平显著升高（p<0.01），但治疗后口服熊去氧胆酸后的血清清除率显著改善（p<0.05）。这些结果表明，短期泼尼松龙治疗可增加慢性活动性肝炎患者肝脏中的甾醇代谢，这是由于胆汁酸肝清除率增加所致。
