Yamanishi Y, Kishimoto Y, Kawasaki H, Hirayama C, Ikawa S
Gastroenterol Jpn. 1981;16(5):472-7. doi: 10.1007/BF02774519.
Serial measurement of serum bile acid levels was carried out in patients with digestive diseases before and after oral loading with 500 mg of ursodeoxycholic acid. In control cases, serum bile acid reached the maximum level 30 min after loading. Elevation also, of cholic, chenodeoxycholic and deoxycholic acid levels was noted in addition to marked enhancement of the ursodeoxycholic acid level. In patients with chronic aggressive hepatitis and cirrhosis, the serum bile acid level was higher than the controls in fasting state, and increased more significantly after loading. On the other hand, in patients with small intestinal disorders, the serum bile acid level in fasting state tended to be lower than the controls, and became significantly lower after loading. Thus, oral ursodeoxycholic acid tolerance test is found to be useful as a diagnostic test for digestive diseases.
对患有消化系统疾病的患者，在口服500毫克熊去氧胆酸前后进行血清胆汁酸水平的连续测量。在对照病例中，血清胆汁酸在服药后30分钟达到最高水平。除了熊去氧胆酸水平显著升高外，胆酸、鹅去氧胆酸和脱氧胆酸水平也有所升高。在慢性活动性肝炎和肝硬化患者中，空腹状态下血清胆汁酸水平高于对照组，服药后升高更显著。另一方面，在患有小肠疾病的患者中，空腹状态下血清胆汁酸水平往往低于对照组，服药后显著降低。因此，口服熊去氧胆酸耐受性试验被发现可作为消化系统疾病的诊断试验。
