Tiernan Harry, Masud Muhammad, Lange Sawyer, Nanayakkara Shanika, Jayasinghe Thilini N
The University of Sydney School of Dentistry, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
The Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Evid Based Dent. 2025 May 29. doi: 10.1038/s41432-025-01168-x.
AIM: To investigate the effect of maternal smoking during pregnancy (MSDP) on the development of dental conditions in human offspring, as presented in current literature. METHODS: Observational studies from six databases (MEDLINE, Embase, CINAHL, Scopus, Web of Science and Maternity and Infant Care (MIC)) were systematically searched in July 2024. Articles were screened based on their investigation of the effect of MSDP on the development of dental conditions in offspring. Methodological quality was assessed using the Newcastle Ottawa Scale (NOS), while the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. RESULTS: A total of 17 articles were included in this review, focusing on the primary dental developmental outcomes: molar incisor hypomineralisation (MIH), enamel defects (other than MIH), missing teeth, dental eruption, and short root anomaly. Due to high levels of heterogeneity among the studies, meta-analysis was not performed. The majority of studies demonstrated good methodological quality (n = 10), with three assessed as fair and four as poor. The quality of evidence was categorised, with three outcomes receiving a low quality of evidence classification, and tooth eruption and short root anomaly being classed as very low quality. Statistically significant associations between MSDP and each dental outcome had varied results across studies. Most studies concluded an association between MSDP and conditions such as enamel defects (other than MIH), missing teeth, and short root anomaly. Some studies found associations with MIH, while the majority found no link between MSDP and tooth eruption in offspring. CONCLUSION: This review suggests a potential association between MSDP and dental development conditions in offspring. However, due to the low quality of evidence and inconsistencies in findings across observational studies, a definitive association cannot be drawn. Further, novel and high-quality research is needed to understand the impact MSDP on dental development in offspring.
目的：根据当前文献，探讨孕期母亲吸烟（MSDP）对人类后代牙齿状况发育的影响。 方法：2024年7月，系统检索了六个数据库（MEDLINE、Embase、CINAHL、Scopus、Web of Science和母婴护理数据库（MIC））中的观察性研究。根据对MSDP对后代牙齿状况发育影响的研究进行文章筛选。使用纽卡斯尔渥太华量表（NOS）评估方法学质量，同时使用推荐分级、评估、制定和评价（GRADE）方法评估证据质量。 结果：本综述共纳入17篇文章，重点关注主要牙齿发育结果：磨牙切牙矿化不全（MIH）、牙釉质缺陷（MIH除外）、牙齿缺失、牙齿萌出和短根异常。由于研究之间存在高度异质性，未进行荟萃分析。大多数研究显示出良好的方法学质量（n = 10），三项评估为中等，四项评估为较差。证据质量进行了分类，三项结果被归类为低质量证据，牙齿萌出和短根异常被归类为极低质量。MSDP与每个牙齿结果之间的统计学显著关联在各研究中结果各异。大多数研究得出MSDP与牙釉质缺陷（MIH除外）、牙齿缺失和短根异常等状况之间存在关联。一些研究发现与MIH有关联，而大多数研究未发现MSDP与后代牙齿萌出之间存在联系。 结论：本综述表明MSDP与后代牙齿发育状况之间可能存在关联。然而，由于证据质量低以及观察性研究结果不一致，无法得出明确的关联。此外，需要新颖且高质量的研究来了解MSDP对后代牙齿发育的影响。
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