Zhang Zhiyang, Hu Jialei, Ding Hanfeng, Zhang Li, Rao Peirong
School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
Beilstein J Org Chem. 2025 May 12;21:926-934. doi: 10.3762/bjoc.21.75. eCollection 2025.
A convergent approach for the enantioselective construction of an advanced intermediate containing the [5,5,6,6]-tetracyclic core framework of the khayanolide-type limonoids was described. The strategy features an acylative kinetic resolution of the benzylic alcohol, a 1,2-Grignard addition and an AcOH-interrupted Nazarov cyclization.
描述了一种对映选择性构建包含卡亚诺内酯型柠檬苦素[5,5,6,6]-四环核心骨架的高级中间体的汇聚方法。该策略的特点是苄醇的酰化动力学拆分、1,2-格氏加成和乙酸中断的纳扎罗夫环化反应。
