Mori Kazuki, Rikimaru Kentaro, Kan Toshiyuki, Fukuyama Tohru
Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Org Lett. 2004 Sep 2;6(18):3095-7. doi: 10.1021/ol048857e.
[reaction: see text] The stereoselective synthesis of the tetracyclic intermediate 21 for (+)-naphthyridinomycin (1) has been accomplished. The convergent synthesis used the Ugi 4CC reaction with the amine derivative 10. The key features of the stereoselective synthesis of 21 were the intramolecular Mizoroki-Heck reaction, an aromatic-aldehyde cyclization, and a stereoselective hydroboration.
[反应：见正文] 已完成对（+）-萘啶霉素（1）的四环中间体21的立体选择性合成。该汇聚合成使用了胺衍生物10的Ugi 4CC反应。21的立体选择性合成的关键特征是分子内Mizoroki-Heck反应、芳醛环化反应和立体选择性硼氢化反应。
