Varsha V K, Girish H C, Kamat Mamata, Doddawad Vidya G
Department of Oral Pathology & Microbiology, Rajarajeshwari Dental College and Hospital, Bengaluru, Karnataka, India.
Department of Oral Pathology & Microbiology, Bharati Vidyapeeth (Deemed to be University) Pune, Dental College and Hospital, Sangli, Maharashtra. India.
Ethiop J Health Sci. 2024 May;34(3):251-254. doi: 10.4314/ejhs.v34i3.10.
Salivary gland tumors make up a relatively small proportion, ranging from 1% to 4%, of all neoplasms in the human body. Among these, pleomorphic adenoma stands out as a distinct benign tumor of the salivary glands, characterized by a combination of epithelial and mesenchymal elements.Only 0.3% to 1.5%, of biopsies in oral and Maxillofacial pathology laboratories are associated with tumors originating from minor salivary glands. Keratinizing pleomorphic adenoma, a rare variant accounting for 5-10% of all pleomorphic adenomas, differs from the typical form due to the presence of keratin within the tumor cells, serving as a distinguishing histological feature. The incidence of keratinizing pleomorphic adenoma is not well-established but is believed to be less than 1 case per 100,000 people per year. Here we present an atypical histopathological variation of pleomorphic adenoma, featuring extensive keratinization and manifesting in a less typical anatomical location in a 57-year-old male patient.
唾液腺肿瘤在人体所有肿瘤中所占比例相对较小，为1%至4%。其中，多形性腺瘤是唾液腺一种独特的良性肿瘤，其特征是上皮和间充质成分的组合。口腔颌面病理实验室中只有0.3%至1.5%的活检与源自小唾液腺的肿瘤有关。角化性多形性腺瘤是一种罕见的变体，占所有多形性腺瘤的5%-10%，由于肿瘤细胞内存在角蛋白，与典型形式不同，这是一种独特的组织学特征。角化性多形性腺瘤的发病率尚未明确，但据信每年每10万人中不到1例。在此，我们报告一例多形性腺瘤的非典型组织病理学变异，其特征为广泛角化，发生在一名57岁男性患者不太典型的解剖部位。
