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pubCounteR:一个R软件包,用于在用户定义的生物学背景下,针对通过实验得出的基因列表查询已发表文献。

pubCounteR: an R package for interrogating published literature for experimentally-derived gene lists within a user-defined biological context.

作者信息

Leer Marina, Soultoukis George A, Jähnert Markus, Oveisi Masoome, Walther Dirk, Schulz Tim J

机构信息

Department of Adipocyte Development, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.

German Center for Diabetes Research (DZD), Neuherberg, Germany.

出版信息

Front Bioinform. 2025 May 6;5:1523184. doi: 10.3389/fbinf.2025.1523184. eCollection 2025.

Abstract

Basic and clinical biomedical research relies heavily on modern large-scale datasets that include genomics, transcriptomics, epigenomics, metabolomics, and proteomics, among other "Omics". These research tools very often generate lists of candidate genes that are hypothesized or shown to be responsible for the biological effect in question. To aid the biological interpretation of experimentally-obtained gene lists, we developed pubCounteR, an R-package and web-based interface that screens publications by a user-defined set of keywords representing a specific biological context for experimentally-derived gene lists.

摘要

基础和临床生物医学研究严重依赖于现代大规模数据集,这些数据集包括基因组学、转录组学、表观基因组学、代谢组学和蛋白质组学等其他“组学”。这些研究工具经常生成候选基因列表,这些基因被假设或证明与所讨论的生物学效应有关。为了帮助对实验获得的基因列表进行生物学解释,我们开发了pubCounteR,这是一个R包和基于网络的界面,它通过一组用户定义的关键词来筛选出版物,这些关键词代表了实验衍生基因列表的特定生物学背景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ddc/12118352/bcd451801d6b/fbinf-05-1523184-g001.jpg

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