Rezaee Malihe, Bastan Mohammad-Mahdi, Yaghoobi Alireza, Behnoush Amir Hossein, Hosseini Kaveh
Tehran Heart Center Tehran University of Medical Sciences Tehran Iran.
Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran Iran.
J Am Heart Assoc. 2025 Jun 3;14(11):e039158. doi: 10.1161/JAHA.124.039158. Epub 2025 May 29.
High systolic blood pressure (HSBP) is a significant public health issue, increasing the risk of various chronic and acute diseases. This study comprehensively analyzes the HSBP-attributed burden in the Eastern Mediterranean Region (EMR).
We extracted and analyzed data on deaths, disability-adjusted life-years (DALYs), years of life lost, years lived with disability, and summary exposure values (SEVs) related to HSBP from the Global Burden of Disease (GBD) 2021 study for the EMR countries from 1990 to 2021.
In 2021, HSBP accounted for an estimated age-standardized death rate of 228.4 (95% UI: 189.6 to 266) and DALYs rate of 4554.9 (3719.7 to 5279.6) per 100,000 population in the EMR. From 1990 to 2021, there was a 12.7% and 14.1% decline in age-standardized death and DALYs rates linked to HSBP, respectively, with greater reduction among women. During this period, all countries except Pakistan and Libya experienced a decrease in age-standardized death and DALYs rates, and also countries with higher socio-demographic index (SDI) reported a lower burden attributable to HSBP in 2021. Despite the overall reduction in burden, age-standardized SEVs of HSBP increased by 21.3% (12.2% to 31.7%) from 1990 to 2021, with a more significant rise in men than in women.
While the HSBP-attributed burden has decreased in the EMR from 1990 to 2021, the increasing trend in age-standardized SEVs indicates a rising exposure. Therefore, implementing effective strategies aimed at further reducing the burden and exposure values of HSBP in this region is essential.
高收缩压是一个重大的公共卫生问题，会增加各种慢性和急性疾病的风险。本研究全面分析了东地中海区域（EMR）中高收缩压所致的负担。
我们从《2021年全球疾病负担（GBD）研究》中提取并分析了1990年至2021年期间EMR国家与高收缩压相关的死亡、伤残调整生命年（DALYs）、寿命损失年数、带病生存年数以及汇总暴露值（SEVs）的数据。
2021年，在EMR地区，高收缩压估计导致的年龄标准化死亡率为每10万人228.4（95%不确定区间：189.6至266），DALYs率为每10万人4554.9（3719.7至5279.6）。从1990年到2021年，与高收缩压相关的年龄标准化死亡率和DALYs率分别下降了12.7%和14.1%，女性下降幅度更大。在此期间，除巴基斯坦和利比亚外，所有国家的年龄标准化死亡率和DALYs率均有所下降，而且社会人口指数（SDI）较高的国家在2021年报告的高收缩压所致负担较低。尽管总体负担有所减轻，但从1990年到2021年，高收缩压的年龄标准化SEVs增加了21.3%（12.2%至31.7%），男性的增幅比女性更为显著。
虽然从1990年到2021年EMR地区高收缩压所致负担有所下降，但年龄标准化SEVs的上升趋势表明暴露水平在增加。因此，实施旨在进一步减轻该地区高收缩压负担和暴露值的有效策略至关重要。
