Wang Wei, Chi Xinyu, Ji Jianyu, Zhang Junlin, Xiang Shulin, Xiong Bin, Pang Jing
Department of Intensive Care Unit, The Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.
Medicine (Baltimore). 2025 May 30;104(22):e42603. doi: 10.1097/MD.0000000000042603.
While previous studies have investigated the pathophysiology, epidemiology, and risk factors of invasive pulmonary aspergillosis (IPA), research trends and hotspots on this topic remain relatively unexplored. This study aims to develop a visual knowledge map using bibliometric analysis to identify research hotspots and predict future trends in IPA research. A systematic search was conducted on the Web of Science Core Collection for articles published between January 1, 2000, and March 31, 2024. Tools such as CiteSpace and VOSviewer were used to analyze annual publication trends, contributions by countries, institutions, journals, authors, and references, as well as key research areas to identify current hotspots and future directions. A total of 4058 articles were included, representing contributions from 3409 institutions across 749 journals and 214 countries or regions. The United States published the most articles (1312) and emerged as the most influential country in this field. Medical Mycology published the highest number of articles (206), while Clinical Infectious Diseases was the most cited journal (27,450 citations). Keyword clustering revealed 4 major themes: diagnostics (e.g., galactomannan assays), clinical management (e.g., antifungal therapy), at-risk populations (e.g., transplant recipients), and emerging trends (e.g., COVID-19-associated IPA). Temporal analysis identified 3 distinct research phases: early phase (2000-2007): focus on bone marrow transplantation and diagnostic methods. mid-phase (2008-2018): emphasis on clinical guidelines and epidemiological studies. Recent phase (2019-2024): shift toward COVID-19-associated IPA and its impacts. By applying bibliometric methods to analyze IPA research, this study identifies key authors, countries, institutions, and journals in terms of collaboration and influence. It enhances the understanding of research hotspots in the field and provides insights into potential future collaborations and research directions.
虽然先前的研究已经调查了侵袭性肺曲霉病（IPA）的病理生理学、流行病学和危险因素，但该主题的研究趋势和热点仍相对未被探索。本研究旨在使用文献计量分析方法绘制可视化知识图谱，以识别IPA研究的热点并预测未来趋势。我们在科学网核心合集上进行了系统检索，查找2000年1月1日至2024年3月31日期间发表的文章。使用CiteSpace和VOSviewer等工具分析年度发表趋势、各国、机构、期刊、作者和参考文献的贡献，以及关键研究领域，以确定当前热点和未来方向。共纳入4058篇文章，这些文章来自749种期刊、214个国家或地区的3409个机构。美国发表的文章最多（1312篇），成为该领域最具影响力的国家。《医学真菌学》发表的文章数量最多（206篇），而《临床传染病》是被引用次数最多的期刊（27450次引用）。关键词聚类揭示了4个主要主题：诊断（如半乳甘露聚糖检测）、临床管理（如抗真菌治疗）、高危人群（如移植受者）和新趋势（如COVID-19相关的IPA）。时间分析确定了3个不同的研究阶段：早期阶段（2000 - 2007年）：重点是骨髓移植和诊断方法。中期阶段（2008 - 2018年）：强调临床指南和流行病学研究。近期阶段（2019 - 2024年）：转向COVID-19相关的IPA及其影响。通过应用文献计量方法分析IPA研究，本研究从合作和影响力方面识别了关键作者、国家、机构和期刊。它增进了对该领域研究热点的理解，并为潜在的未来合作和研究方向提供了见解。
