West China Hospital, West China School of Nursing, Sichuan University, 37 Guo Xue Rd., Chengdu 610041, China.
Nutrients. 2023 Jun 29;15(13):2947. doi: 10.3390/nu15132947.
Vitamin D has been suggested to play a role in the development of depression, but the nature of the relationship between the two is still not fully understood. Although some studies have shown an association between vitamin D deficiency and depression, others have yielded inconsistent or inconclusive results. As a result, further research is needed to better understand the relationship between vitamin D and depression.
This study aims to assess the association between serum vitamin D and the risk of depressive symptoms in individuals aged 20 years and older in the United States.
We selected 7562 participants from the 2007-2018 US National Health and Nutrition Examination Survey (NHANES). Participants' serum vitamin D levels were determined from laboratory data, and those with a Patient Health Questionnaire-9 (PHQ-9) score of ≥ 10 were considered to have depressive symptoms. Associations between vitamin D and depressive symptoms were investigated using multiple logistic regression, subgroup analysis, and smoothed curve fitting.
In our study, 11.17% of the participants had depression. Multiple regression stratified analysis showed a significant inverse association between serum vitamin D and depression in the 29-39 years age group after full adjustment (OR = 0.54, 95% CI: 0.31-0.95, = 0.0316). This result was supported by subgroup analysis and smoothed curve fitting.
The association between serum vitamin D and depressive status in US adults varied across populations. Among those aged 29-39 years, vitamin D supplementation tended to show a lower rate of depression.
维生素 D 被认为在抑郁症的发展中起作用，但两者之间的关系性质仍不完全清楚。虽然一些研究表明维生素 D 缺乏与抑郁症之间存在关联，但其他研究得出的结果不一致或没有结论。因此，需要进一步的研究来更好地了解维生素 D 和抑郁症之间的关系。
本研究旨在评估美国 20 岁及以上人群血清维生素 D 与抑郁症状风险之间的关系。
我们从 2007-2018 年美国国家健康和营养调查（NHANES）中选择了 7562 名参与者。参与者的血清维生素 D 水平由实验室数据确定，PHQ-9 评分≥10 的被认为患有抑郁症状。使用多变量逻辑回归、亚组分析和平滑曲线拟合来研究维生素 D 与抑郁症状之间的关联。
在我们的研究中，11.17%的参与者患有抑郁症。经过充分调整后，29-39 岁年龄组的多变量回归分层分析显示血清维生素 D 与抑郁之间存在显著负相关（OR=0.54，95%CI：0.31-0.95，=0.0316）。亚组分析和平滑曲线拟合结果支持这一结果。
美国成年人血清维生素 D 与抑郁状态之间的关联因人群而异。在 29-39 岁年龄组中，维生素 D 补充剂似乎与较低的抑郁发生率相关。
