Sebag J, Feke G T, Delori F C, Weiter J J
Invest Ophthalmol Vis Sci. 1985 Oct;26(10):1415-22.
This study attempts to establish whether neurogenic optic atrophy induces changes in anterior optic nerve circulation and to determine how noninvasive techniques of measuring blood flow in vivo compare to microsphere distribution. Five cats underwent unilateral optic nerve transection in the orbital apex and a sham procedure in the contralateral eye. Two to three months later, no abnormalities were detected by fluorescein angiography. Laser Doppler measurements demonstrated a 53% decrease in red blood cell speed through the capillaries of the atrophic optic nerve heads in vivo. Optic disk reflectance measurements of anterior optic nerve blood volume in vivo demonstrated a 51% decrease in the estimated blood volume of the capillaries in atrophic optic nerve heads. Flow was calculated on the basis of these noninvasive measurements and demonstrated an average decrease of 74% in optic atrophy. Histologic studies of microsphere distribution demonstrated an average decrease of 80% in flow to the anterior optic nerve in optic atrophy. These results suggest that anterior optic nerve blood flow is significantly reduced in primary neurogenic optic atrophy. This study also demonstrates that the noninvasive measurements of blood flow are substantiated by histologic evaluation of microsphere distribution.
本研究试图确定神经源性视神经萎缩是否会引起视神经前部血液循环的变化，并确定体内测量血流的非侵入性技术与微球分布相比如何。五只猫在眶尖进行了单侧视神经横断术，对侧眼进行假手术。两到三个月后，荧光素血管造影未发现异常。激光多普勒测量显示，体内萎缩性视乳头毛细血管中红细胞速度下降了53%。体内对视神经前部血容量的视盘反射测量显示，萎缩性视乳头毛细血管估计血容量下降了51%。根据这些非侵入性测量计算出血流量，结果显示视神经萎缩平均下降了74%。微球分布的组织学研究表明，视神经萎缩时视神经前部血流平均下降了80%。这些结果表明，原发性神经源性视神经萎缩时视神经前部血流显著减少。本研究还表明，血流的非侵入性测量结果得到了微球分布组织学评估的证实。
