Gerges Petra, Kfoury Miriana, Landy David, Fourmentin Sophie, Greige-Gerges Hélène
Faculty of Medicine, American University of Beirut, Lebanon.
Univ. Littoral Cote d'Opale, UR 4492, UCEIV, Unité de Chimie Environnementale et Interactions sur le Vivant, Dunkerque, France.
Carbohydr Polym. 2025 Sep 1;363:123712. doi: 10.1016/j.carbpol.2025.123712. Epub 2025 May 8.
Cyclodextrins (CDs) are cyclic oligosaccharides primarily used as excipients in the formulation of drugs, including those intended for pulmonary delivery. CDs have gained increased attention for their use as drug solubilizers. The beneficial role they play in the formulation of drugs intended for lung targeting has received particular attention in recent years, along with the potential benefits this route offers for achieving systemic effects. Hence, various CDs based materials have been considered in literature including CD/drug inclusion complexes, polymerized CDs and nanosponges, metal-organic frameworks, CDs in proliposomes, and others. The investigation of CDs as active agents is also considered in literature for the treatment of lungs diseases. The literature provides a large range of information on the manufacturing of CD-based materials for pulmonary delivery, the characterization of the obtained formulations, their suitability for lung deposition, the pharmacokinetics of the drugs when loaded in a particular formulation, and the resulting biological effects, yet the challenges of their clinical translation remain to be addressed.
环糊精（CDs）是环状寡糖，主要用作药物制剂中的辅料，包括用于肺部给药的药物。环糊精作为药物增溶剂的应用受到了越来越多的关注。近年来，它们在肺部靶向药物制剂中所起的有益作用以及这种给药途径实现全身效应的潜在益处受到了特别关注。因此，文献中考虑了各种基于环糊精的材料，包括环糊精/药物包合物、聚合环糊精和纳米海绵、金属有机框架、前体脂质体中的环糊精等。文献中也考虑了将环糊精作为活性剂用于治疗肺部疾病。文献提供了大量关于用于肺部给药的基于环糊精材料的制造、所得制剂的表征、它们对肺部沉积的适用性、药物负载在特定制剂中的药代动力学以及由此产生的生物学效应的信息，然而它们临床转化的挑战仍有待解决。
