[F]FDG PET/CT Predicts Patient Survival in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease.

There are few effective prognostic biomarkers in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). We investigated the potential of [F]FDG PET/CT to predict mortality in this population. In total, 45 patients with SSc-ILD (12 men and 33 women; age, 58.9 ± 9.9 y) were prospectively recruited for [F]FDG PET/CT, forming the largest cohort of this type to our knowledge. All patients underwent clinical assessment, including multidisciplinary team review, high-resolution CT evaluation, and pulmonary function tests. The maximum pulmonary uptake on [F]FDG PET/CT (SUV), minimum pulmonary uptake in unaffected or background lung (SUV), and target-to-background ratio (TBR) (SUV/SUV) were quantified using region-of-interest analysis. Kaplan-Meier analysis identified associations with mortality. Associations between [F]FDG PET/CT measurements, pulmonary function tests, and the established model based on sex, age, and lung physiology (known as ILD-GAP) to predict mortality were performed. Stepwise forward Wald-Cox analysis assessed the independence of significant [F]FDG PET/CT measurements from the ILD-GAP index. Synergies between pulmonary [F]FDG PET/CT measurements and ILD-GAP index for risk stratification in patients with SSc-ILD were investigated. Forty-five patients with SSc-ILD were followed for a mean of 44.8 ± 26.1 mo, with 15 deaths (33%) recorded. The mean ± SD SUV was 3.2 ± 1.1, SUV was 0.5 ± 0.3, and TBR was 6.8 ± 2.6. Increased mortality was associated with high pulmonary SUV ( = 0.027), high SUV ( = 0.002), low TBR ( = 0.016), low forced vital capacity ( = 0.021), low carbon monoxide diffusion coefficient ( = 0.021), low transfer factor ( = 0.012), high ILD-GAP score ( = 0.010), and high ILD-GAP index ( = 0.005). Multivariate Cox regression analysis revealed that pulmonary SUV (hazard ratio, 4.2; 95% CI, 1.3-13.4; = 0.017) and ILD-GAP index (hazard ratio, 3.9; 95% CI, 1.2-12.8; = 0.024) were the only independent predictors of overall survival. Combining [F]FDG uptake with ILD-GAP score data in a modified ILD-GAP index refined the ability to predict mortality ( < 0.002). High-background [F]FDG uptake in normal-appearing lung independently predicts overall survival in SSc-ILD and may stratify patients' risk when combined with ILD-GAP score data in a modified ILD-GAP index. High pulmonary [F]FDG uptake is associated with increased mortality in patients with SSc-ILD.