Lv Xinxin, Yang Xue, Lv Xinying, Huang Jiaping, Dai Anna, Jin Lingling, Huang Hao
Periodontology Specialty Clinic, Department of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
Department of Stomatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
BMC Oral Health. 2025 May 29;25(1):847. doi: 10.1186/s12903-025-06211-y.
Patients with aplastic anemia are at increased risk of bleeding, which often limits conventional periodontal treatment. Although drug-induced gingival overgrowth is well-documented, its management in this high-risk population has not been thoroughly studied.
We respectively reviewed the cases of seven aplastic anemia patients (4 males, 3 females; aged 33-57) with cyclosporine-associated drug-induced gingival overgrowth who were treated with initial periodontal therapy (IPT) under hematologist supervision from May 2018 to October 2024. Within 1-6 months follow-up visit, 6 of 7 patients achieved complete resolution of gingival overgrowth. One patient with severe overgrowth and concurrent felodipine use required 15 months for full resolution. Two cases of postoperative bleeding were controlled by removing chronic inflammatory tissue. One patient experienced recurrence after discontinuing follow-up for 2 years. No infections occurred during treatment.
IPT can safely and effectively treat severe drug-induced gingival overgrowth in patients with aplastic anemia. A maintenance therapy frequency of no less than once every three months is crucial to prevent recurrence in these patients.
再生障碍性贫血患者出血风险增加，这常常限制了传统的牙周治疗。尽管药物性牙龈增生已有充分记录，但其在这一高危人群中的管理尚未得到充分研究。
我们回顾了2018年5月至2024年10月期间在血液科医生监督下接受初始牙周治疗（IPT）的7例再生障碍性贫血患者（4例男性，3例女性；年龄33 - 57岁）与环孢素相关的药物性牙龈增生病例。在1 - 6个月的随访中，7例患者中有6例牙龈增生完全消退。1例严重增生且同时使用非洛地平的患者需要15个月才能完全消退。2例术后出血通过清除慢性炎症组织得到控制。1例患者在停止随访2年后复发。治疗期间未发生感染。
IPT可以安全有效地治疗再生障碍性贫血患者严重的药物性牙龈增生。每三个月不少于一次的维持治疗频率对于预防这些患者复发至关重要。
