Wang Mingtao, Shi Yifeng, Huang Jianrong, Xiao Liping, Fan Jie
Key Lab of Applied Chemistry of Zhejiang Province, Department of Chemistry, Zhejiang University Hangzhou 310027 China
Hangzhou Zeolite-Innovation Life Science Technology Co., Ltd Hangzhou 310018 China.
RSC Adv. 2025 May 29;15(22):17819-17828. doi: 10.1039/d5ra02291f. eCollection 2025 May 21.
Wound treatment is a complex and lengthy process that involves rapid hemostasis in the early stage and the prevention of bacterial infection in the later stage. Generally, these two functions are separately achieved by different materials or medicines, thereby causing a lot of inconvenience and pain to patients. In this work, four calcium-copper-based zeolites (CaCuZ) with zeolite P, Y, X, and A structures were fabricated from corresponding sodium-based zeolites ion exchange. Among these materials, the material with a zeolite P structure possesses better hemostatic performance than those with zeolite X and zeolite Y structures, and it shows improved antibacterial performance compared with the materials containing zeolite A and zeolite X structures. When the copper content of the CaCuZ material with the zeolite P structure is in the range of 0.64-6.30 mg g, the clotting time of blood plasma is less than 2.5 min, the bacteriostasis rates against () and () are higher than 95%, and there is no obvious cytotoxicity towards 3T3 cells. A satisfactory balance in the clotting time, bacteriostasis, and cytotoxicity is achieved in this material, and the material integrates excellent hemostatic and antibacterial properties, offering great application prospects in wound treatment.
伤口治疗是一个复杂且漫长的过程，早期需要快速止血，后期需要预防细菌感染。一般来说，这两种功能分别由不同的材料或药物来实现，从而给患者带来诸多不便和痛苦。在这项工作中，通过相应的钠基沸石离子交换制备了具有沸石P、Y、X和A结构的四种钙铜基沸石（CaCuZ）。在这些材料中，具有沸石P结构的材料比具有沸石X和沸石Y结构的材料具有更好的止血性能，并且与含有沸石A和沸石X结构的材料相比，它表现出更好的抗菌性能。当具有沸石P结构的CaCuZ材料的铜含量在0.64 - 6.30 mg/g范围内时，血浆凝血时间小于2.5分钟，对（）和（）的抑菌率高于95%，并且对3T3细胞没有明显的细胞毒性。这种材料在凝血时间、抑菌和细胞毒性方面实现了令人满意的平衡，并且该材料兼具优异的止血和抗菌性能，在伤口治疗中具有广阔的应用前景。
