antitumor capacity of extracts obtained from the plants (Sacha inchi) and in gastric cancer.

BACKGROUND

Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B or higher cancers. and (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity.

METHODS

In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of , the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).

RESULTS

All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations seed oil showed 95% mortality at 1% concentration (CC = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic leaf extract also inhibited cell migration.

CONCLUSION

, leaf extracts and seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.