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从植物（印加果）中提取的提取物在胃癌中的抗肿瘤能力。

antitumor capacity of extracts obtained from the plants (Sacha inchi) and in gastric cancer.

作者信息

Vargas Jose, Arbelaez Natalia, Cardenas Denny, Murillo Javier, Ospina Victoria, Robledo Sara, Soto Javier

机构信息

BIOGEN-Universidad de Santander, Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Cúcuta, Colombia.

PECET-Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

出版信息

F1000Res. 2025 May 27;14:194. doi: 10.12688/f1000research.158563.2. eCollection 2025.

DOI:10.12688/f1000research.158563.2
PMID:40443907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12120421/
Abstract

BACKGROUND

Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B or higher cancers. and (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity.

METHODS

In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of , the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).

RESULTS

All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations seed oil showed 95% mortality at 1% concentration (CC = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic leaf extract also inhibited cell migration.

CONCLUSION

, leaf extracts and seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.

摘要

背景

胃癌是全球第五大常见癌症，也是癌症死亡的第三大主要原因。围手术期或辅助化疗可提高IB期及以上癌症患者的生存率。据报道，印加果（Sacha inchi）能增强多种生物学功能，包括抗肿瘤和抗增殖活性。

方法

为了评估这些植物叶片粗提物以及印加果种子油中存在的这种潜力，根据这些衍生物对AGS细胞（CRL-1739）不同生物学参数（如细胞毒性、增殖、细胞周期、凋亡等）的影响来确定其抗肿瘤活性。

结果

所有测试提取物在90和160μg/ml浓度下均具有细胞毒性，印加果种子油在1%浓度下显示出95%的死亡率（CC50 = 46.7%）。细胞增殖受到抑制，所有提取物均影响细胞周期，但印加果种子油显著诱导AGS细胞在亚G1期积累，诱导DNA片段化作为细胞死亡机制。乙醇提取的印加果叶提取物也抑制细胞迁移。

结论

印加果、印加果叶提取物和印加果种子油有可能成为抗肿瘤产品。需要在胃癌小鼠模型中进一步验证，以进一步研究这些提取物的抗肿瘤潜力，并继续开发有助于治疗这类肿瘤的草药产品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/6fd261f9cffb/f1000research-14-182185-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/84dd8e4e4030/f1000research-14-182185-g0000.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/77dd7ee9a585/f1000research-14-182185-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/5ada2571b708/f1000research-14-182185-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/57f59fdd2505/f1000research-14-182185-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/354c0b987591/f1000research-14-182185-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/6fd261f9cffb/f1000research-14-182185-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/84dd8e4e4030/f1000research-14-182185-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/7b45fd16feed/f1000research-14-182185-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/a83aa73c5767/f1000research-14-182185-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/02f927b7946c/f1000research-14-182185-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/77dd7ee9a585/f1000research-14-182185-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/5ada2571b708/f1000research-14-182185-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/57f59fdd2505/f1000research-14-182185-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/354c0b987591/f1000research-14-182185-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a87b/12120548/6fd261f9cffb/f1000research-14-182185-g0008.jpg

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