从接受肾衰竭治疗患者的血液透析带隧道带涤纶套导管尖端组装多重耐药生物膜形成基因组。
assembly of multidrug resistant biofilm forming genome from hemodialysis tunneled cuffed catheter tips of patients undergoing renal failure treatment.
作者信息
Adhikary Rajsekhar, Sarkar Indrani, Patel Dhara, Gang Sishir, Nath Uttam Kumar, Hazra Saugata
机构信息
Department of Bioscience and Bioengineering, Indian Institute of Technology-Roorkee, Roorkee, Uttarakhand, India.
Department of Medical Oncology and Haematology, AIIMS, Rishikesh, Uttarakhand, India.
出版信息
Microbiol Resour Announc. 2025 Jul 10;14(7):e0009525. doi: 10.1128/mra.00095-25. Epub 2025 May 30.
Abstract
HL_Chru_C was isolated from the hemodialysis tunneled cuffed catheter tip of renal failure patients. Whole-genome sequencing (WGS) revealed a 2,494,573 bp genome with 12 contigs, 72% GC content, and 2,240 protein-coding genes. The computational prediction of penicillin-binding proteins and biofilm-forming signaling gene cassettes may contribute to the resistance mechanisms.
摘要
HL_Chru_C是从肾衰竭患者的血液透析带隧道带 cuff 导管尖端分离出来的。全基因组测序（WGS）显示其基因组大小为2,494,573 bp，有12个重叠群，GC含量为72%，编码2,240个蛋白质的基因。青霉素结合蛋白和生物膜形成信号基因盒的计算预测可能有助于其耐药机制。
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