You Yanwei, Zheng Kefeng, Ablitip Alimjan, Wang Dizhi, Chen Chaofan, Liu Yajing, Chen Yuquan, Ma Xindong
Division of Sports Science & Physical Education, Tsinghua University, Beijing, China; IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Division of Sports Science & Physical Education, Tsinghua University, Beijing, China; IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
J Adolesc Health. 2025 Jul;77(1):84-93. doi: 10.1016/j.jadohealth.2025.03.023. Epub 2025 May 30.
To examine the association between adherence to Life's Essential 8 (LE8) and depression in a nationally representative sample of US emerging adults, including both overall and subgroup analyses by gender, age, and other sociodemographic factors.
Data from 2,219 emerging adults from the National Health and Nutrition Examination Survey (2007-2018) were analyzed. Depression was measured using the Patient Health Questionnaire-9, with scores ≥10 indicating depression. LE8 scores were calculated based on cardiovascular health factors, and covariates included demographic and behavioral variables. Weighted logistic regression was used to assess associations between LE8 and depression.
Participants with higher LE8 scores had lower odds of depression. In the fully adjusted model, which adjusted for sociodemographic variables, the odds of depression were significantly lower in the highest quartile of LE8 adherence (odds ratio (OR) = 0.252, 95% confidence interval (CI): 0.233-0.289, p < .001) compared to the lowest quartile. Continuous LE8 scores were also inversely associated with depression (OR = 0.961, 95% CI: 0.949-0.974, p < .001). Gender-stratified analyses showed that the protective effect of higher LE8 scores was more pronounced in males (OR = 0.956, 95% CI: 0.934-0.979, p < .001) than in females (OR = 0.960, 95% CI: 0.945-0.975, p < .001).
Better cardiovascular health, as indicated by higher LE8 scores, was strongly linked to lower depression in emerging adults. Targeted interventions promoting key behaviors like sleep and physical activity could effectively reduce depression in this population.
在美国具有全国代表性的青年成人样本中，研究坚持“生命八要素”（LE8）与抑郁之间的关联，包括按性别、年龄和其他社会人口学因素进行的总体分析和亚组分析。
对来自国家健康与营养检查调查（2007 - 2018年）的2219名青年成人的数据进行分析。使用患者健康问卷-9来测量抑郁，得分≥10表明存在抑郁。基于心血管健康因素计算LE8得分，协变量包括人口统计学和行为变量。采用加权逻辑回归来评估LE8与抑郁之间的关联。
LE8得分较高的参与者患抑郁症的几率较低。在对社会人口学变量进行调整的完全调整模型中，与最低四分位数相比，LE8坚持程度最高的四分位数中抑郁的几率显著降低（优势比（OR）= 0.252，95%置信区间（CI）：0.233 - 0.289，p <.001）。连续的LE8得分也与抑郁呈负相关（OR = 0.961，95% CI：0.949 - 0.974，p <.001）。按性别分层分析表明，LE8得分较高的保护作用在男性中（OR = 0.956，95% CI：0.934 - 0.979，p <.001）比在女性中（OR = 0.960，95% CI：0.945 - 0.975，p <.001）更为明显。
较高的LE8得分表明更好的心血管健康与青年成人较低的抑郁密切相关。促进睡眠和体育活动等关键行为的针对性干预措施可以有效降低该人群的抑郁。
