Silina M V, Dzhalilova D Sh, Diatroptova M A, Grin O O, Babaev M A, Makarova O V
Petrovsky National Research Centre of Surgery, Moscow, Russia.
Bull Exp Biol Med. 2025 Apr;178(6):691-696. doi: 10.1007/s10517-025-06399-7. Epub 2025 May 30.
The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of HIF1A expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.
在使用体外循环进行心脏手术后发生的全身炎症反应，具有其病程的个体特征，对其活动的围手术期评估可为制定个性化方法以预测术后并发症的发生和病程严重程度提供依据。我们发现，术后感染和炎症并发症高风险患者的特征是术前以及术后24小时和72小时血液中HIF-1α和VNN1蛋白水平较高，且术后72小时白细胞中HIF1A表达水平较高。所获得的数据对于理解手术干预后发生的全身炎症反应病程的个体特征以及在重症监护期间及时治疗器官功能障碍是必要的。
