Moseley Garrett A, Ross Leanna M, Collins-Bennett Katherine A, North Rebecca, Johnson Johanna L, Kraus William E
Duke University School of Medicine, Durham, North Carolina, United States.
Duke Molecular Physiology Institute, Duke University School of Medicine Durham, Durham, North Carolina, United States.
J Appl Physiol (1985). 2025 Jun 1;138(6):1532-1542. doi: 10.1152/japplphysiol.00743.2024. Epub 2025 May 30.
Assess the cumulative effects of different weekly exercise energy expenditures, with similar total program volume and intensity, on cardiorespiratory fitness (CRF) and metabolic syndrome (MetS). Following the 9-mo Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) trial, 22 participants continued exercise training for 6-24 mo in one of two groups: ) low-amount/vigorous-intensity (LAVI; = 14): 14 kcal/kg/wk (KKW) at 65%-80% peak V̇o and ) high-amount/vigorous-intensity (HAVI; = 8): 23 KKW at 65%-80% peak V̇o. Outcomes included absolute (AV̇o) and relative peak oxygen consumption (RV̇o), body fat percentage, waist circumference, HDL-C, triglycerides, fasting glucose, insulin sensitivity index (S), and modified MetS score. Group comparisons were made at equivalent and differential timepoints with similar total exercise volumes. S improvements were greater in HAVI compared with LAVI at the LAVI 21-mo/HAVI 15-mo contrast (mean difference ± SD: 2.13 ± 0.68 mU/L/min, = 0.008). AV̇o and RV̇o improvements were greater in HAVI at both the LAVI 21-mo/HAVI 15-mo contrast (model estimate [95% CI]: 0.21 [0.01, 0.40] L/min, = 0.038 and 3.05 [0.14, 5.96] mL/kg/min, = 0.041), respectively, and the LAVI 33-mo/HAVI 21-mo contrast (0.25 [0.04, 0.45] L/min, = 0.022 and 3.21 [0.10, 6.32] mL/kg/min, = 0.044). These AV̇o contrasts remained significant after adjusting for age and sex. Adherence declined over time. When cumulative exercise volumes were similar, body composition and MetS markers adapted similarly between groups. However, continued training at greater weekly volumes of vigorous exercise resulted in more substantial CRF and S improvements compared with lesser weekly volumes. Findings suggest factors beyond total energy expenditure-such as exercise frequency or duration-may modulate some longitudinal health improvements. This exploratory analysis investigated longitudinal effects of accumulating similar total exercise program volumes at different weekly exercise energy expenditures on cardiorespiratory fitness and metabolic syndrome measures over months to years. In general, adaptations are similar; however, factors other than total energy cost-such as exercise frequency or duration-may modulate longitudinal improvements in cardiorespiratory fitness and skeletal muscle insulin sensitivity over 33 mo of training among sedentary adults with overweight or obesity and dyslipidemia.
评估在总计划量和强度相似的情况下，不同每周运动能量消耗对心肺适能（CRF）和代谢综合征（MetS）的累积影响。在为期9个月的通过特定运动进行有针对性的风险降低干预研究（STRRIDE）试验之后，22名参与者在以下两组中的一组继续进行6至24个月的运动训练：）低运动量/高强度（LAVI；n = 14）：以65%-80%峰值摄氧量进行14千卡/千克/周（KKW）的运动；）高运动量/高强度（HAVI；n = 8）：以65%-80%峰值摄氧量进行23 KKW的运动。结果包括绝对峰值摄氧量（AV̇o）和相对峰值摄氧量（RV̇o）、体脂百分比、腰围、高密度脂蛋白胆固醇（HDL-C）、甘油三酯、空腹血糖、胰岛素敏感性指数（S）和改良的MetS评分。在总运动量相似的等效和不同时间点进行组间比较。在LAVI组21个月/HAVI组15个月的对比中，HAVI组的S改善幅度大于LAVI组（平均差异±标准差：2.13±0.68毫单位/升/分钟，P = 0.008）。在LAVI组21个月/HAVI组15个月的对比中，HAVI组的AV̇o和RV̇o改善幅度更大（模型估计[95%置信区间]：0.21[0.01, 0.40]升/分钟，P = 0.038和3.05[0.14, 5.96]毫升/千克/分钟，P = 0.041），以及在LAVI组33个月/HAVI组21个月的对比中（0.25[0.04, 0.45]升/分钟，P = 0.022和3.21[0.10, 6.32]毫升/千克/分钟，P = 0.044）。在调整年龄和性别后，这些AV̇o对比仍具有显著性。依从性随时间下降。当累积运动量相似时，两组之间的身体成分和MetS标志物的适应性相似。然而，与每周较小运动量相比，继续进行每周较大运动量的剧烈运动导致CRF和S有更显著的改善。研究结果表明，除了总能量消耗之外的因素，如运动频率或持续时间，可能会调节一些纵向健康改善情况。这项探索性分析研究了在数月至数年的时间里，在不同每周运动能量消耗下累积相似总运动计划量对心肺适能和代谢综合征指标的纵向影响。总体而言，适应性相似；然而，除了总能量消耗之外的因素，如运动频率或持续时间，可能会调节超重或肥胖以及血脂异常的久坐成年人在33个月训练期间心肺适能和骨骼肌胰岛素敏感性的纵向改善情况。
