Steiner R A, Schiller H S, Illner P, Blandau R, Gale C C
Lab Anim Sci. 1977 Apr;27(2):217-21.
Daily measurement of serum luteinizing hormone, estradiol-17beta, and progesterone were made during the menstrual cycle in nine pigtail macaques (Macaca nemestrina). All data were normalized to the day of the luteinizing hormone peak. Serum estradiol-17beta increased from approximately 100 pg/ml during the early follicular phase to 442 +/- 156 pg/ml during the maximum midcycle concomitant with the luteinizing hormone peak, and a small increase in serum estradiol-17beta was observed during the luteal phase coincident with the progesterone peak. Serum progesterone values increased slightly at the time of the luteinizing hormone peak and increased from 0.2-0.3 ng/ml during the midfollicular phase to peak levels of 8.3 +/- 1.75 ng/ml 9 days after the luteinizing hormone surge. Serum luteinizing hormone remained low and relatively constant throughout the early and midcycle, then sharply increased approximately four-fold to peak values of 6.25 +/- 0.9 ng/ml. Sex skin swelling increased slowly during the follicular phase and declined slowly throughout the early luteal phase. Rectal temperature did not change significantly throughout the menstrual cycle. The similarity of plasma sex hormone changes during the menstrual cycle between women and the pigtail macaque suggested that this nonhuman primate should be a useful animal model for studying human reproduction.
在9只豚尾猕猴（食蟹猴）的月经周期中，每日测定血清促黄体生成素、雌二醇-17β和孕酮。所有数据均以促黄体生成素峰值日为基准进行标准化。血清雌二醇-17β在卵泡早期约为100 pg/ml，在月经周期中期峰值时升至442±156 pg/ml，与促黄体生成素峰值同时出现，且在黄体期与孕酮峰值同时出现时，血清雌二醇-17β有小幅升高。血清孕酮值在促黄体生成素峰值时略有增加，从卵泡中期的0.2 - 0.3 ng/ml升至促黄体生成素激增后9天的峰值8.3±1.75 ng/ml。血清促黄体生成素在月经周期早期和中期一直保持较低且相对稳定，然后急剧增加约四倍，达到峰值6.25±0.9 ng/ml。性皮肤肿胀在卵泡期缓慢增加，在黄体早期缓慢下降。直肠温度在整个月经周期中无显著变化。女性和豚尾猕猴月经周期中血浆性激素变化的相似性表明，这种非人灵长类动物应是研究人类生殖的有用动物模型。
