Kono S, Ikeda M, Tokudome S, Nishizumi M, Kuratsune M
J Cancer Res Clin Oncol. 1985;110(2):161-4. doi: 10.1007/BF00402732.
A cohort of 5,477 male Japanese physicians was studied to examine the relationship between smoking habits and mortalities from cancer, coronary heart disease (CHD) and stroke over 12.7 years. The logistic regression analysis based on proportional hazard models was used for statistical assessment. The risks of both lung cancer and CHD were strongly associated with smoking habits in terms of the number of cigarettes smoked per day, inhalation level and age at starting to smoke. These associations were not influenced by the effect of drinking habits. However, the risk increment of lung cancer due to cigarette smoking was fairly small as compared with the data from other studies of male Caucasians. A statistically significant association was observed between upper aerodigestive cancer and cigarette smoking. But this relationship became insignificant after adjustment for drinking habits, and the risk of heavy smokers was drastically reduced. No clear association was noted between smoking and mortalities from gastric cancer and stroke.
对5477名日本男性医生组成的队列进行了为期12.7年的研究，以检验吸烟习惯与癌症、冠心病（CHD）和中风死亡率之间的关系。基于比例风险模型的逻辑回归分析用于统计评估。肺癌和冠心病的风险在每天吸烟数量、吸入程度和开始吸烟的年龄方面与吸烟习惯密切相关。这些关联不受饮酒习惯的影响。然而，与其他男性白种人的研究数据相比，吸烟导致肺癌的风险增量相当小。在上消化道癌症与吸烟之间观察到统计学上显著的关联。但在调整饮酒习惯后，这种关系变得不显著，重度吸烟者的风险大幅降低。未发现吸烟与胃癌和中风死亡率之间有明显关联。
