Kono S, Ikeda M, Tokudome S, Yoshimura T, Nishizumi M, Kuratsune M
J Cancer Res Clin Oncol. 1985;109(1):82-5. doi: 10.1007/BF01884260.
The relationship between alcohol and site-specific cancers was investigated in a follow-up study of 5,139 male Japanese physicians. Information on drinking habits was obtained by mail questionnaire in 1965, and cancer deaths over 12.7 years were analyzed with drinking habits classified into five categories; nondrinker, ex-drinker, occasional drinker, and daily drinker whose intake of alcohol was equivalent to less than 2 or 2 and more go of sake (1 go sake congruent to 27 ml alcohol). Both age and smoking habits were taken into account in the calculation of death rates based on man-years at risk. Logistic regression analysis was also performed on cummulative mortality data. Upper aerodigestive cancer was strongly associated with alcohol consumption, giving some confidence in the validity of the present study. Excluding ex-drinkers, the risk of stomach cancer and liver cancer was gradually increased from nondrinkers to daily drinkers with lower intake of alcohol, but no further increase was noted for daily drinkers with larger consumption. Logistic regression did not show any significant associations between drinking habits and these two cancers, but the number of deaths from liver cancer was still small. Not particular patterns were observed for cancers of the large bowel and lung.
在一项对5139名日本男性医生的随访研究中，调查了酒精与特定部位癌症之间的关系。1965年通过邮寄问卷获取饮酒习惯信息，并对12.7年期间的癌症死亡情况进行分析，饮酒习惯分为五类：不饮酒者、戒酒者、偶尔饮酒者以及每日饮酒量相当于少于2合或2合及以上清酒的每日饮酒者（1合清酒相当于27毫升酒精）。在基于危险人年计算死亡率时，考虑了年龄和吸烟习惯。还对累积死亡率数据进行了逻辑回归分析。上消化道癌症与酒精消费密切相关，这为本研究的有效性提供了一定信心。排除戒酒者后，胃癌和肝癌的风险从不饮酒者到酒精摄入量较低的每日饮酒者逐渐增加，但酒精消费量较大的每日饮酒者未出现进一步增加。逻辑回归未显示饮酒习惯与这两种癌症之间有任何显著关联，但肝癌死亡人数仍然较少。对于结肠癌和肺癌，未观察到特定模式。
