Meng Xin, Feng Yanan, Wang Yuanyuan, Lin Chen, Wang Wei, Zhu Sutian, Guo Bing, Wang Huaiyu, Sun Litao, Yan Fei
Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China; Department of Ultrasound Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450052 Zhengzhou, China.
Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China.
Ultrason Sonochem. 2025 Aug;119:107398. doi: 10.1016/j.ultsonch.2025.107398. Epub 2025 May 24.
Photothermal therapy (PTT) has emerged as a promising new approach in tumor treatment, with the great advantages including non-invasiveness and temporal controllability. However, the effective delivery of photothermal agents into tumor remains a significant challenge, limiting its clinical translational application. In this study, we developed a kind of photothermal agents modified with gas vesicles (GVs), greatly facilitating ultrasound/fluorescence imaging-guided delivery of photothermal agents and enhancing the efficacy of photothermal therapy. The GVs were synthesized and extracted from Halobacterium NRC-1, followed with modification with IR808. The resulting GVs-IR808 were able to be visually tracked by ultrasound and fluorescence imaging. Upon their arrival at the tumor area after systemic administration, ultrasound irradiation was applied to induce the cavitation of GVs-IR808, greatly promoting IR808 delivery into the tumor. The subsequent laser irradiation was applied and resulted in a significant inhibition of tumor growth. In conclusion, our study provides a novel approach for ultrasound/fluorescence dual-modal imaging-guided photothermal treatment of breast tumors.
光热疗法（PTT）已成为肿瘤治疗中一种很有前景的新方法，具有非侵入性和时间可控性等巨大优势。然而，将光热剂有效递送至肿瘤部位仍然是一项重大挑战，限制了其临床转化应用。在本研究中，我们开发了一种用气体囊泡（GVs）修饰的光热剂，极大地促进了超声/荧光成像引导的光热剂递送，并提高了光热疗法的疗效。从嗜盐菌NRC-1中合成并提取GVs，然后用IR808进行修饰。所得的GVs-IR808能够通过超声和荧光成像进行可视化追踪。全身给药后，当它们到达肿瘤区域时，施加超声照射以诱导GVs-IR808的空化，极大地促进IR808递送至肿瘤。随后施加激光照射，结果显著抑制了肿瘤生长。总之，我们的研究为超声/荧光双模态成像引导的乳腺肿瘤光热治疗提供了一种新方法。
