血清镁水平对血液透析患者颈动脉内膜中层厚度的影响。

Effect of serum magnesium level on carotid intima media thickness in hemodialysis patients.

作者信息

Kara Ali Veysel, Ozdemir Ridvan, Inan Hamza, Ozdemir Beyza Ozerten, Hayme Serhat, Cosgun Muharrem Said

机构信息

Faculty of Medicine, Department of Nephrology, Erzincan Binali Yildirim University, Erzincan, Turkey.

Faculty of Medicine, Department of Internal Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey.

出版信息

BMC Nephrol. 2025 May 30;26(1):270. doi: 10.1186/s12882-025-04168-2.

DOI:10.1186/s12882-025-04168-2

PMID:40448043

Abstract

BACKGROUND

We aimed to examine whether serum magnesium level is related to cardiovascular events in hemodialysis patients by investigating the relationship between serum magnesium (Mg) level and carotid intima media thickness (CIMT).

METHODS

In this cross-sectional study, we evaluated 88 hemodialysis patients. The mean CIMT of these patients was measured and recorded by doppler ultrasonography. Patients were divided into two groups according to their serum magnesium level. Correlation analysis and linear regression analysis were used to define the relationship between study parameters. We divided our patients into 2 groups according to Mg value as group 1 (Mg ≥ 2.3 mg/dl) and group 2 (Mg < 2.3 mg/dl).

RESULTS

The mean CIMT of patients with group 1 and group 2 were respectively 0.93 ± 0.22 mm and 1.03 ± 0.22 mm. There was statistically significant difference between two groups in terms of the mean CIMT value (p = 0.045). We found negative, low-level, statistically significant correlations between Mg and mean CIMT (r=-0.272; p = 0.010), calcium and mean CIMT (r: -0.221, p: 0.039) and hemoglobin and mean CIMT (r: -0.215, p: 0.044). According to regression analysis, serum magnesium level and age were found independent risk factors for mean CIMT value (p: 0.004 and p: 0.045).

CONCLUSIONS

We found a significant relationship between serum Mg level and CIMT, which indicates carotid atherosclerosis.

摘要

背景

我们旨在通过研究血清镁（Mg）水平与颈动脉内膜中层厚度（CIMT）之间的关系，来探讨血清镁水平是否与血液透析患者的心血管事件相关。

方法

在这项横断面研究中，我们评估了88例血液透析患者。通过多普勒超声测量并记录这些患者的平均CIMT。根据患者的血清镁水平将其分为两组。采用相关性分析和线性回归分析来确定研究参数之间的关系。我们根据镁值将患者分为两组，即第1组（Mg≥2.3mg/dl）和第2组（Mg＜2.3mg/dl）。

结果

第1组和第2组患者的平均CIMT分别为0.93±0.22mm和1.03±0.22mm。两组之间的平均CIMT值存在统计学显著差异（p = 0.045）。我们发现镁与平均CIMT之间存在负性、低水平且具有统计学显著性的相关性（r = -0.272；p = 0.010），钙与平均CIMT之间（r：-0.221，p：= 0.039）以及血红蛋白与平均CIMT之间（r：-0.215，p：= 0.044）也存在类似情况。根据回归分析，血清镁水平和年龄是平均CIMT值的独立危险因素（p：0.004和p：0.045）。