Walz Karla C, Suchodolski Jan S, Werner Melanie, Grimm Felix, Schnyder Manuela, Zablotski Yury, Unterer Stefan
Clinic for Small Animal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, TAMU, Texas, USA.
J Vet Intern Med. 2025 Jul-Aug;39(4):e70123. doi: 10.1111/jvim.70123.
In humans, there is a high prevalence of postinfectious irritable bowel syndrome (IBS) after acute giardiasis.
To evaluate the prevalence of chronic gastrointestinal and dermatologic signs in dogs after acute Giardia-associated gastroenteritis.
Forty-nine dogs with acute gastroenteritis and confirmed Giardia infection and fifty control dogs without a history of acute giardiasis.
Retrospective longitudinal study. Data were collected from dogs with acute gastrointestinal signs and confirmed Giardia infection at a young age (< 9 months) and from healthy controls matched by breed, sex, and age. After a minimum follow-up period of 12 months, dog owners completed a questionnaire assessing chronic gastrointestinal and dermatologic signs later in life. Severity of chronic disease was quantified using a modified canine inflammatory bowel disease activity index (CIBDAI). Univariable logistic regression was used to compare frequencies of chronic signs between groups.
Dogs with acute giardiasis at a young age had a higher prevalence of chronic intestinal signs (Giardia 29%, 14/49; controls 10%, 5/50; p = 0.03) and pruritus (Giardia 33%, 16/49; controls 8%, 4/50; p = 0.01) later in life than did control dogs. A high canine acute diarrhea severity (CADS) index during acute enteritis, combined with metronidazole treatment, increased the risk of developing chronic gastrointestinal signs (p = 0.04).
Juvenile dogs with acute gastroenteritis and confirmed Giardia infection had a higher prevalence of pruritus and chronic gastrointestinal signs. Severe enteritis and metronidazole administration may increase the risk of developing chronic gastrointestinal signs.
在人类中，急性贾第虫病后感染后肠易激综合征（IBS）的患病率很高。
评估急性贾第虫相关性胃肠炎后犬慢性胃肠道和皮肤体征的患病率。
49只患有急性胃肠炎且确诊贾第虫感染的犬以及50只无急性贾第虫病史的对照犬。
回顾性纵向研究。收集幼年（<9个月）患有急性胃肠道体征且确诊贾第虫感染的犬以及按品种、性别和年龄匹配的健康对照犬的数据。在至少12个月的随访期后，犬主人完成一份问卷，评估犬后期生活中的慢性胃肠道和皮肤体征。使用改良的犬炎症性肠病活动指数（CIBDAI）对慢性疾病的严重程度进行量化。采用单变量逻辑回归比较两组慢性体征的发生频率。
幼年患有急性贾第虫病的犬在后期生活中出现慢性肠道体征（贾第虫感染组29%，14/49；对照组10%，5/50；p = 0.03）和瘙痒（贾第虫感染组33%，16/49；对照组8%，4/50；p = 0.01）的患病率高于对照犬。急性肠炎期间高犬急性腹泻严重程度（CADS）指数，联合甲硝唑治疗，增加了出现慢性胃肠道体征的风险（p = 0.04）。
患有急性胃肠炎且确诊贾第虫感染的幼年犬瘙痒和慢性胃肠道体征的患病率较高。严重肠炎和使用甲硝唑可能会增加出现慢性胃肠道体征的风险。
