急性出血性腹泻后犬慢性胃肠道疾病体征的频率。
Frequency of signs of chronic gastrointestinal disease in dogs after an episode of acute hemorrhagic diarrhea.
机构信息
Clinic of Small Animal Internal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-University, Munich, Germany.
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
出版信息
J Vet Intern Med. 2022 Jan;36(1):59-65. doi: 10.1111/jvim.16312. Epub 2021 Dec 10.
BACKGROUND
Acute enteropathy is a trigger of chronic gastrointestinal (GI) disease in humans.
OBJECTIVE
To report the prevalence of and explore possible risk factors for signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD).
ANIMALS
One hundred and fifty-one dogs, 80 dogs with a historical diagnosis of AHD, 71 control dogs with no history of AHD.
METHODS
In this retrospective longitudinal study, data were collected from dogs with a historical diagnosis of AHD and healthy controls matched by breed, age and sex, aged between 1 year and 15 years of age, for which a follow-up of at least 12 months after enrolment was available. Dog owners responded to a questionnaire to determine the history of signs of chronic GI disease.
RESULTS
There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P = .03; odds ratio = 2.57; confidence interval [CI] 95% 1.12-6.31) over a similar observation time (median 4 years; range, 1-12 years).
CONCLUSIONS AND CLINICAL IMPORTANCE
Severe intestinal mucosal damage and associated barrier dysfunction might trigger chronic GI disease later in life.
背景
急性肠炎是人类慢性胃肠道（GI）疾病的一个诱因。
目的
报告犬急性出血性腹泻（AHD）发作后出现慢性 GI 疾病体征的患病率，并探讨可能的危险因素。
动物
151 只狗，80 只狗有 AHD 的历史诊断，71 只对照狗没有 AHD 的历史。
方法
在这项回顾性纵向研究中，对有 AHD 历史诊断的犬和健康对照犬（按品种、年龄和性别匹配）进行了数据收集，年龄在 1 至 15 岁之间，在登记后至少有 12 个月的随访。狗主人回答了一份问卷，以确定慢性 GI 疾病的病史。
结果
与对照组相比，以前发生过 AHD 的犬出现慢性 GI 疾病体征的患病率更高（AHD 28%；对照组 13%；P =.03；比值比 2.57；95%置信区间 [CI] 95% 1.12-6.31），观察时间相似（中位数 4 年；范围 1-12 年）。
结论和临床意义
严重的肠黏膜损伤和相关的屏障功能障碍可能在以后的生活中引发慢性 GI 疾病。
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