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细胞外囊泡的脂质组成：在诊断和治疗递送中的应用。

The lipid composition of extracellular vesicles: applications in diagnostics and therapeutic delivery.

作者信息

Ghadami Samaneh, Dellinger Kristen

机构信息

Department of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T State University, Greensboro, NC, United States.

出版信息

Front Mol Biosci. 2023 Jul 13;10:1198044. doi: 10.3389/fmolb.2023.1198044. eCollection 2023.

DOI:10.3389/fmolb.2023.1198044
PMID:37520326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10381967/
Abstract

Extracellular vesicles (EVs), including exosomes, with nanoscale sizes, biological origins, various functions, and unique lipid and protein compositions have been introduced as versatile tools for diagnostic and therapeutic medical applications. Numerous studies have reported the importance of the lipid composition of EVs and its influence on their mechanism of action. For example, changes in the lipidomic profile of EVs have been shown to influence the progression of various diseases, including ovarian malignancies and prostate cancer. In this review, we endeavored to examine differences in the lipid content of EV membranes derived from different cell types to characterize their capabilities as diagnostic tools and treatments for diseases like cancer and Alzheimer's disease. We additionally discuss designing functionalized vesicles, whether synthetically by hybrid methods or by changing the lipid composition of natural EVs. Lastly, we provide an overview of current and potential biomedical applications and perspectives on the future of this growing field.

摘要

细胞外囊泡（EVs），包括外泌体，具有纳米级尺寸、生物来源、多种功能以及独特的脂质和蛋白质组成，已被作为诊断和治疗医学应用的多功能工具引入。大量研究报道了EVs脂质组成的重要性及其对其作用机制的影响。例如，已表明EVs脂质组学特征的变化会影响包括卵巢恶性肿瘤和前列腺癌在内的各种疾病的进展。在本综述中，我们致力于研究源自不同细胞类型的EV膜脂质含量的差异，以表征其作为癌症和阿尔茨海默病等疾病的诊断工具和治疗手段的能力。我们还讨论了设计功能化囊泡，无论是通过混合方法合成还是通过改变天然EVs的脂质组成。最后，我们概述了当前和潜在的生物医学应用以及对这个不断发展的领域未来的展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/103b09b392fa/fmolb-10-1198044-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/99e2dc402d99/fmolb-10-1198044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/103b09b392fa/fmolb-10-1198044-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/9d51d5809b00/fmolb-10-1198044-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/69755d123749/fmolb-10-1198044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/9553baeabf6c/fmolb-10-1198044-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/ca5db53eefef/fmolb-10-1198044-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/8af20310f612/fmolb-10-1198044-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/99e2dc402d99/fmolb-10-1198044-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00e5/10381967/103b09b392fa/fmolb-10-1198044-g007.jpg

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