Khosravi Ali, Boldaji Fatollah, Dastar Behrouz, Torshizi Mohammad Amir Karimi, Alemi Morteza, Hoseinifar Seyed Hossein
Department of Animal and Poultry Nutrition, Faculty of Animal Science, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, 49189-4364, Iran.
Department of Poultry Nutrition, Tarbiat Modares University, Tehran, 14115-336, Iran.
Sci Rep. 2025 May 31;15(1):19164. doi: 10.1038/s41598-025-04459-6.
Modulating the intestinal microbiota of birds by using probiotics and prebiotics to reduce mortality and increase poultry health is a method of interest in the poultry industry. This study aimed to determine the best combination of synbiosis between Enterococcus faecium and one of the four prebiotics: mannan oligosaccharide (MOS), oligofructose (OF), xylooligosaccharide (XOS) or galactooligosaccharide (GOS). Based on the results of laboratory studies, a synbiotic was selected for performance evaluation in broiler chickens. Based on the results of in vitro studies, E. faecium + GOS combination was selected for further study as a potential synbiotic. Four hundred broiler chickens of the Cobb 500 breed were randomly assigned to 4 experimental treatments, and each repetition had 20 birds of one-day-old chickens, males, and females. Experimental treatments included control, control + prebiotic GOS, control + E.faecium probiotic, and control + selected synbiotic. After six weeks of feeding, growth performance, immune response, and intestinal microbiota were evaluated. Administration of GOS and E.faecium as synbiotic positively affected performance, especially in the first periods of production (P < 0.05). Treatments containing synbiotic and prebiotic significantly reduced the population of E. coli compared to the control treatment (P < 0.05). These results showed that E.faecium + GOS can be an efficient synbiotic for broiler chickens. However, determining the selected synbiotic effects on challenged broiler chickens is a point of interest that merits further research.
利用益生菌和益生元调节家禽肠道微生物群以降低死亡率并提高家禽健康水平,是家禽业关注的一种方法。本研究旨在确定粪肠球菌与四种益生元之一:甘露寡糖(MOS)、低聚果糖(OF)、木寡糖(XOS)或低聚半乳糖(GOS)之间共生的最佳组合。根据实验室研究结果,选择一种合生元用于肉鸡的性能评估。基于体外研究结果,选择粪肠球菌+GOS组合作为潜在的合生元进行进一步研究。400只科宝500品种的肉鸡被随机分配到4种实验处理中,每个重复有20只一日龄的雏鸡,包括雄性和雌性。实验处理包括对照组、对照组+益生元GOS、对照组+粪肠球菌益生菌和对照组+选定的合生元。饲养六周后,评估生长性能、免疫反应和肠道微生物群。将GOS和粪肠球菌作为合生元给药对性能有积极影响,尤其是在生产的最初阶段(P<0.05)。与对照处理相比,含有合生元和益生元的处理显著降低了大肠杆菌的数量(P<0.05)。这些结果表明,粪肠球菌+GOS可以成为肉鸡的一种有效合生元。然而,确定选定的合生元对受挑战肉鸡的影响是一个值得进一步研究的关注点。