Garg Kunal, Booth Rachael, Cobey Aiven, Gilbert Leona, Ozdemir Aylin
Tezted Ltd, Jyväskylä, Finland.
Dr. O Care, Ponte Vedra Beach, FL, USA.
Integr Med (Encinitas). 2025 Jun;24(3):10-27.
BACKGROUND/OBJECTIVES: Lyme disease (LD) and its co-infections present significant diagnostic and treatment challenges due to their complex interplay with neurological symptoms, immune responses, autoimmune reactions, and mental health conditions. Standard two-tier LD testing often fails to detect cases, necessitating expanded serologic and functional testing. Following CARE Guidelines, this case series examines ten clinical narratives of LD, highlighting the limitations of standard diagnostic methods, the potential benefits of specialized testing, and the need for an effective paradigm for LD management.
A multidisciplinary approach grounded in integrative medicine was adopted. Diagnostic methods included advanced serological panels (e.g., TICKPLEX), co-infection testing, functional immune markers, Cunningham Panel testing for neuropsychiatric Lyme presentations, and imaging. Treatments included traditional antibiotics, botanical antimicrobials (Cryptolepis, Artemisinin, Biocidin), mitochondrial and neuroprotective support (CoQ10, NAD+, magnesium), nutritional therapies, detox support, immune system support protocols, pulsed electromagnetic field therapy, and methylene blue protocols.
The findings from this case series demonstrate the heterogeneity of LD manifestations across different ages, genders, and backgrounds. Compared to promising specialized testing, standard laboratory tests often misdiagnose LD and its co-infections as Parkinson's disease, multiple sclerosis, lupus, autism, and psychiatric disorders. Furthermore, integrating diverse treatment modalities, including combination and rotational antibiotic therapy, IV ceftriaxone for neurological cases, detoxification support (glutathione IV, vitamin C IV), and immune modulation with intravenous immunoglobulin, helped manage symptoms. Herxheimer reactions were effectively managed with antioxidant and detox therapies. Patients receiving long-term maintenance therapies, including herbal antimicrobials and gut microbiome support, showed fewer relapses.
This case series advocates for a holistic, patient-centered approach. It emphasizes the necessity of comprehensive diagnostics that consider external factors, including post-vaccine symptom exacerbations, immune dysregulation, personalized treatment strategies, and ongoing research to improve LD management. These findings provide an evidence-based framework for physicians to integrate conventional and natural medicine strategies to optimize LD care.
背景/目的：莱姆病（LD）及其合并感染因其与神经症状、免疫反应、自身免疫反应和心理健康状况的复杂相互作用，在诊断和治疗方面存在重大挑战。标准的两级莱姆病检测常常无法检测出病例，因此需要扩大血清学和功能检测。遵循CARE指南，本病例系列研究了10例莱姆病的临床病例，突出了标准诊断方法的局限性、专门检测的潜在益处以及建立有效莱姆病管理模式的必要性。
采用以整合医学为基础的多学科方法。诊断方法包括先进的血清学检测组合（如TICKPLEX）、合并感染检测、功能性免疫标志物、针对神经精神性莱姆病表现的坎宁安检测组合以及影像学检查。治疗方法包括传统抗生素、植物抗菌剂（白叶藤、青蒿素、Biocidin）、线粒体和神经保护支持（辅酶Q10、烟酰胺腺嘌呤二核苷酸、镁）、营养疗法、排毒支持、免疫系统支持方案、脉冲电磁场疗法和亚甲蓝方案。
该病例系列的研究结果表明，莱姆病表现因年龄、性别和背景的不同而具有异质性。与前景良好的专门检测相比，标准实验室检测常常将莱姆病及其合并感染误诊为帕金森病、多发性硬化症、狼疮、自闭症和精神障碍。此外，综合多种治疗方式，包括联合和轮换抗生素治疗、针对神经病例的静脉注射头孢曲松、排毒支持（静脉注射谷胱甘肽、静脉注射维生素C）以及静脉注射免疫球蛋白进行免疫调节，有助于控制症状。赫克斯海默反应通过抗氧化和排毒疗法得到有效控制。接受长期维持治疗的患者，包括植物抗菌剂和肠道微生物群支持，复发次数较少。
本病例系列提倡采用整体的、以患者为中心的方法。它强调全面诊断的必要性，这种诊断要考虑外部因素，包括疫苗接种后症状加重、免疫失调、个性化治疗策略以及为改善莱姆病管理而进行的持续研究。这些发现为医生整合传统医学和自然医学策略以优化莱姆病护理提供了一个循证框架。
