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化合物K可抑制由白细胞介素-17A处理和紫外线B照射诱导的表皮衰老。

Compound K suppresses epidermal aging induced by IL-17A treatment and UVB irradiation.

作者信息

Kim A Young, Jung Ji-Yong, Kim Donghyun, Cho Jeong Hun, Hong Yong Deog, Kim Hyoung-June, Cho Si-Young

机构信息

Research and Innovation Center, AMOREPACIFIC, Yongin, Republic of Korea.

出版信息

J Ginseng Res. 2025 May;49(3):326-330. doi: 10.1016/j.jgr.2025.03.004. Epub 2025 Mar 21.

DOI:10.1016/j.jgr.2025.03.004
PMID:40453350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12125580/
Abstract

We evaluated the anti-accelerated epidermal skin aging effects of compound K (CK) on keratinocytes using IL-17A and ultraviolet B. CK restored epidermal functions and reduced the induction of pro-inflammatory cytokines by inhibiting NF-κB and p38 MAPK activation. CK plays a significant role in controlling accelerated epidermal skin aging.

摘要

我们使用白细胞介素-17A和紫外线B评估了化合物K（CK）对角质形成细胞的抗表皮加速衰老作用。CK通过抑制核因子κB（NF-κB）和p38丝裂原活化蛋白激酶（p38 MAPK）的激活来恢复表皮功能并减少促炎细胞因子的诱导。CK在控制表皮加速衰老中发挥着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/63e60aebc365/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/22ffb5040de0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/39c92316cd46/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/ddd777973094/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/c4e71d476fad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/63e60aebc365/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/22ffb5040de0/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/39c92316cd46/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/ddd777973094/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/c4e71d476fad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a69/12125580/63e60aebc365/gr4.jpg

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本文引用的文献

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Sci Rep. 2023 Dec 15;13(1):22357. doi: 10.1038/s41598-023-49886-5.
2
The IL-17 family in diseases: from bench to bedside.IL-17 家族与疾病：从基础到临床。
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3
Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways.
蓝光辐照通过 TGF-β、JNK 和 EGFR 通路诱导人皮肤成纤维细胞皮肤衰老。
J Dermatol Sci. 2023 Aug;111(2):52-59. doi: 10.1016/j.jdermsci.2023.06.007. Epub 2023 Jun 28.
4
Targeting lymphoid-derived IL-17 signaling to delay skin aging.靶向淋巴来源的白介素-17 信号以延缓皮肤衰老。
Nat Aging. 2023 Jun;3(6):688-704. doi: 10.1038/s43587-023-00431-z. Epub 2023 Jun 8.
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Kaempferol tetrasaccharides restore skin atrophy via PDK1 inhibition in human skin cells and tissues: Bench and clinical studies.山奈酚四糖通过抑制 PDK1 恢复人皮肤细胞和组织中的皮肤萎缩：基础和临床研究。
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