• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

物种的生物活性成分与临床潜力。

Bioactive components and clinical potential of species.

作者信息

Li Shuo, Hu Xunpeng, Liu Fen, Hu Weiming

机构信息

Gansu Phamaceutical Industry Innovation Research Institute, Key Laboratory of Quality and Standard of TCM of Gansu Province, Gansu University of Chinese Medicine, Lanzhou, China.

College of pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.

出版信息

Front Pharmacol. 2025 May 16;16:1585697. doi: 10.3389/fphar.2025.1585697. eCollection 2025.

DOI:10.3389/fphar.2025.1585697
PMID:40453655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12122460/
Abstract

L., the world's largest vascular plant genus, has been used medicinally and as food for centuries, especially in traditional Chinese medicine It is widely applied in immune modulation, antioxidant therapy, anti-inflammatory treatments, and antitumor applications. Recent studies show that species is rich in bioactive compounds, such as polysaccharides, flavonoids, saponins, alkaloids, and simple phenolics, which demonstrate significant pharmacological effects, including anti-inflammatory, antioxidant, immunomodulatory, and antitumor properties, along with potential benefits for Alzheimer's disease and diabetes. This review synthesizes 140 references to analyze 51 newly identified flavonoids, 31 triterpenoid saponins, and 19 alkaloids in (2020-2025), focusing on their chemical structures and bioactivities. It also examines species in medicine and food homology (MFH) and how processing methods affect its efficacy. Furthermore, the mechanisms behind its anti-inflammatory, antioxidant, immune-boosting, antitumor, neuroprotective, and hypoglycemic effects are discussed. Future studies should prioritize large-scale clinical trials to confirm 's efficacy and safety, explore combination therapies, and improve sustainable resource utilization to expand its medical and food applications. Keywords: Bioactive molecules, , Pharmacological action, Mechanism of action, Medicine and food homology (MFH).

摘要

L.是世界上最大的维管植物属,几个世纪以来一直被用作药物和食物,尤其是在传统中药中。它广泛应用于免疫调节、抗氧化治疗、抗炎治疗和抗肿瘤应用。最近的研究表明,该属植物富含生物活性化合物,如多糖、黄酮类化合物、皂苷、生物碱和简单酚类,这些化合物具有显著的药理作用,包括抗炎、抗氧化、免疫调节和抗肿瘤特性,以及对阿尔茨海默病和糖尿病的潜在益处。本综述综合了140篇参考文献,分析了2020 - 2025年该属植物中51种新鉴定的黄酮类化合物、31种三萜皂苷和19种生物碱,重点关注它们的化学结构和生物活性。还研究了该属植物的药食同源性以及加工方法如何影响其功效。此外,还讨论了其抗炎、抗氧化、增强免疫、抗肿瘤、神经保护和降血糖作用的机制。未来的研究应优先进行大规模临床试验,以确认该属植物的疗效和安全性,探索联合治疗方法,并提高可持续资源利用,以扩大其医疗和食品应用。关键词:生物活性分子;该属植物;药理作用;作用机制;药食同源性

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/5cf2c1691123/fphar-16-1585697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/e52e814be108/fphar-16-1585697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/797e39bbae29/fphar-16-1585697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/29b1b5c64785/fphar-16-1585697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/5cf2c1691123/fphar-16-1585697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/e52e814be108/fphar-16-1585697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/797e39bbae29/fphar-16-1585697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/29b1b5c64785/fphar-16-1585697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c05a/12122460/5cf2c1691123/fphar-16-1585697-g004.jpg

相似文献

1
Bioactive components and clinical potential of species.物种的生物活性成分与临床潜力。
Front Pharmacol. 2025 May 16;16:1585697. doi: 10.3389/fphar.2025.1585697. eCollection 2025.
2
Biosynthesis and Pharmacological Activities of Flavonoids, Triterpene Saponins and Polysaccharides Derived from .从 中衍生的类黄酮、三萜皂苷和多糖的生物合成及药理活性。
Molecules. 2023 Jun 27;28(13):5018. doi: 10.3390/molecules28135018.
3
Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China.中国药食同源和药食两用品种的生物活性成分的降血糖作用。
Crit Rev Food Sci Nutr. 2020;60(14):2303-2326. doi: 10.1080/10408398.2019.1634517. Epub 2019 Jul 16.
4
Pharmacological effects of Astragalus polysaccharides in treating neurodegenerative diseases.黄芪多糖在治疗神经退行性疾病中的药理作用。
Front Pharmacol. 2024 Aug 2;15:1449101. doi: 10.3389/fphar.2024.1449101. eCollection 2024.
5
Astragalus species: Phytochemistry, biological actions and molecular mechanisms underlying their potential neuroprotective effects on neurological diseases.黄芪属植物:对神经系统疾病潜在神经保护作用的生物活性及分子机制相关的植物化学、生物学作用。
Phytochemistry. 2022 Oct;202:113293. doi: 10.1016/j.phytochem.2022.113293. Epub 2022 Jun 30.
6
Research Progress in the Medicine-Food Dual Use of Astragalus for Gastrointestinal Tumors.黄芪在胃肠道肿瘤药食两用方面的研究进展
J Med Food. 2024 Dec;27(12):1145-1157. doi: 10.1089/jmf.2024.k.0057. Epub 2024 Oct 21.
7
Astragalus species: Insights on its chemical composition toward pharmacological applications.黄芪属植物:对其化学成分在药理学应用方面的见解。
Phytother Res. 2021 May;35(5):2445-2476. doi: 10.1002/ptr.6974. Epub 2020 Dec 16.
8
Flavonoids from the Genus Astragalus: Phytochemistry and Biological Activity.黄芪属植物中的黄酮类化合物:植物化学与生物活性。
Pharmacogn Rev. 2016 Jan-Jun;10(19):11-32. doi: 10.4103/0973-7847.176550.
9
Exploration of the main effective constituent and the mechanism in Astragali Radix in the treatment for doxorubicin-induced nephropathy by integrating metabolomics and molecular docking.基于代谢组学和分子对接整合探究黄芪治疗阿霉素肾病的主要有效成分及作用机制。
J Ethnopharmacol. 2023 Apr 6;305:116074. doi: 10.1016/j.jep.2022.116074. Epub 2022 Dec 25.
10
Therapeutic potential of genus Polygonatum in common neuropsychiatric disorders: The revival of an ancient remedy in modern medicine.黄精属植物在常见神经精神疾病中的治疗潜力:现代医学中一种古老疗法的复兴。
J Ethnopharmacol. 2025 Jun 26;350:120052. doi: 10.1016/j.jep.2025.120052. Epub 2025 May 27.

引用本文的文献

1
Effects of polysaccharide supplementation on growth performance, carcass quality, muscle fiber characteristics, meat quality, and development of finishing pigs.多糖补充剂对育肥猪生长性能、胴体品质、肌纤维特性、肉质及发育的影响。
Front Nutr. 2025 Aug 8;12:1654720. doi: 10.3389/fnut.2025.1654720. eCollection 2025.

本文引用的文献

1
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants.全球糖尿病患病率和治疗趋势 1990 年至 2022 年:基于 14100 万参与者的 1108 项人群代表性研究的汇总分析。
Lancet. 2024 Nov 23;404(10467):2077-2093. doi: 10.1016/S0140-6736(24)02317-1. Epub 2024 Nov 13.
2
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.仿野生黄芪与移栽黄芪化学成分比较及其对心力衰竭的治疗作用
J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118827. doi: 10.1016/j.jep.2024.118827. Epub 2024 Sep 16.
3
Structural characterization of Astragalus polysaccharide-D1 and its improvement of low-dose metformin effect by enriching Staphylococcus lentus.
黄芪多糖-D1 的结构表征及其通过富集迟缓葡萄球菌增强小剂量二甲双胍作用
Int J Biol Macromol. 2024 Jun;272(Pt 1):132860. doi: 10.1016/j.ijbiomac.2024.132860. Epub 2024 Jun 2.
4
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.2022 年全球癌症统计数据:全球 185 个国家和地区 36 种癌症的发病率和死亡率全球估计数。
CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4.
5
[Cancer incidence and mortality in China, 2022].[2022年中国癌症发病率和死亡率]
Zhonghua Zhong Liu Za Zhi. 2024 Mar 23;46(3):221-231. doi: 10.3760/cma.j.cn112152-20240119-00035.
6
Astraoleanosides E-P, oleanane-type triterpenoid saponins from the aerial parts of Astragalus membranaceus Bunge and their β-glucuronidase inhibitory activity.膜荚黄芪地上部分中的苍术烷型三萜皂苷苷元 E-P 及其抑制β-葡萄糖醛酸苷酶活性
Bioorg Chem. 2024 Apr;145:107230. doi: 10.1016/j.bioorg.2024.107230. Epub 2024 Feb 20.
7
First determination of anticancer, cytotoxic, and in silico ADME evaluation of secondary metabolites of endemic Freyn & Bornm.首次对特有植物弗罗因和博恩姆次生代谢产物的抗癌、细胞毒性及计算机辅助药物代谢动力学评价
Turk J Chem. 2021 Oct 5;46(1):169-183. doi: 10.3906/kim-2104-23. eCollection 2022.
8
A new acylated flavonol triglycoside and evaluation of the antioxidant activity of subsp. (Murb.) Emb. & Maire.一个新的酰化黄酮三糖苷和对亚种(Murb.)Emb. & Maire 的抗氧化活性评价。
Nat Prod Res. 2024 Dec;38(24):4524-4529. doi: 10.1080/14786419.2023.2278761. Epub 2023 Nov 11.
9
Cycloartane Saponins from and Their In Vitro Neuroprotective, Antioxidant, and hMAO-B-Inhibiting Effects.来自[具体来源未给出]的环阿尔廷烷皂苷及其体外神经保护、抗氧化和抑制人单胺氧化酶B的作用。
Metabolites. 2023 Jul 19;13(7):857. doi: 10.3390/metabo13070857.
10
Radical Scavenging Capability and Mechanism of Three Isoflavonoids Extracted from Radix Astragali: A Theoretical Study.黄芪三种异黄酮的自由基清除能力及其机制:理论研究。
Molecules. 2023 Jun 28;28(13):5039. doi: 10.3390/molecules28135039.