Li Shuo, Hu Xunpeng, Liu Fen, Hu Weiming
Gansu Phamaceutical Industry Innovation Research Institute, Key Laboratory of Quality and Standard of TCM of Gansu Province, Gansu University of Chinese Medicine, Lanzhou, China.
College of pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Front Pharmacol. 2025 May 16;16:1585697. doi: 10.3389/fphar.2025.1585697. eCollection 2025.
L., the world's largest vascular plant genus, has been used medicinally and as food for centuries, especially in traditional Chinese medicine It is widely applied in immune modulation, antioxidant therapy, anti-inflammatory treatments, and antitumor applications. Recent studies show that species is rich in bioactive compounds, such as polysaccharides, flavonoids, saponins, alkaloids, and simple phenolics, which demonstrate significant pharmacological effects, including anti-inflammatory, antioxidant, immunomodulatory, and antitumor properties, along with potential benefits for Alzheimer's disease and diabetes. This review synthesizes 140 references to analyze 51 newly identified flavonoids, 31 triterpenoid saponins, and 19 alkaloids in (2020-2025), focusing on their chemical structures and bioactivities. It also examines species in medicine and food homology (MFH) and how processing methods affect its efficacy. Furthermore, the mechanisms behind its anti-inflammatory, antioxidant, immune-boosting, antitumor, neuroprotective, and hypoglycemic effects are discussed. Future studies should prioritize large-scale clinical trials to confirm 's efficacy and safety, explore combination therapies, and improve sustainable resource utilization to expand its medical and food applications. Keywords: Bioactive molecules, , Pharmacological action, Mechanism of action, Medicine and food homology (MFH).
L.是世界上最大的维管植物属,几个世纪以来一直被用作药物和食物,尤其是在传统中药中。它广泛应用于免疫调节、抗氧化治疗、抗炎治疗和抗肿瘤应用。最近的研究表明,该属植物富含生物活性化合物,如多糖、黄酮类化合物、皂苷、生物碱和简单酚类,这些化合物具有显著的药理作用,包括抗炎、抗氧化、免疫调节和抗肿瘤特性,以及对阿尔茨海默病和糖尿病的潜在益处。本综述综合了140篇参考文献,分析了2020 - 2025年该属植物中51种新鉴定的黄酮类化合物、31种三萜皂苷和19种生物碱,重点关注它们的化学结构和生物活性。还研究了该属植物的药食同源性以及加工方法如何影响其功效。此外,还讨论了其抗炎、抗氧化、增强免疫、抗肿瘤、神经保护和降血糖作用的机制。未来的研究应优先进行大规模临床试验,以确认该属植物的疗效和安全性,探索联合治疗方法,并提高可持续资源利用,以扩大其医疗和食品应用。关键词:生物活性分子;该属植物;药理作用;作用机制;药食同源性