Department of Epidemiology, College of Public Health & Health Professions and College of Medicine, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA.
West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA.
Geroscience. 2023 Feb;45(1):359-369. doi: 10.1007/s11357-022-00638-9. Epub 2022 Aug 11.
Telomeres shorten with age and shorter leukocyte telomere length (LTL) has been associated with various age-related diseases. Thus, LTL has been considered a biomarker of biological aging. Dyslipidemia is an established risk factor for most age-related metabolic disorders. However, little is known about the relationship between LTL and dyslipidemia. Lipidomics is a new biochemical technique that can simultaneously identify and quantify hundreds to thousands of small molecular lipid species. In a large population comprising 1843 well-characterized American Indians in the Strong Heart Family Study, we examined the lipidomic profile of biological aging assessed by LTL. Briefly, LTL was quantified by qPCR. Fasting plasma lipids were quantified by untargeted liquid chromatography-mass spectrometry. Lipids associated with LTL were identified by elastic net modeling. Of 1542 molecular lipids identified (518 known, 1024 unknown), 174 lipids (36 knowns) were significantly associated with LTL, independent of chronological age, sex, BMI, hypertension, diabetes status, smoking status, bulk HDL-C, and LDL-C. These findings suggest that altered lipid metabolism is associated with biological aging and provide novel insights that may enhance our understanding of the relationship between dyslipidemia, biological aging, and age-related diseases in American Indians.
端粒会随着年龄的增长而缩短，白细胞端粒长度（LTL）较短与各种与年龄相关的疾病有关。因此，LTL 被认为是生物衰老的生物标志物。血脂异常是大多数与年龄相关的代谢紊乱的既定危险因素。然而，人们对 LTL 与血脂异常之间的关系知之甚少。脂质组学是一种新的生化技术，可以同时识别和定量数百到数千种小分子脂质种类。在一项由 1843 名特征明确的美洲印第安人组成的大型研究中，我们研究了通过 LTL 评估的生物衰老的脂质组学特征。简而言之，通过 qPCR 定量 LTL。通过非靶向液相色谱-质谱法定量测定空腹血脂。通过弹性网络模型鉴定与 LTL 相关的脂质。在鉴定的 1542 种分子脂质中（518 种已知，1024 种未知），174 种脂质（36 种已知）与 LTL 独立相关，与年龄、性别、BMI、高血压、糖尿病状态、吸烟状况、HDL-C 总量和 LDL-C 无关。这些发现表明，脂质代谢的改变与生物衰老有关，并提供了新的见解，可能有助于我们理解血脂异常、生物衰老和美洲印第安人年龄相关疾病之间的关系。
