Sun Xue, Liu Yang, Liu Yan, Ai Shaozheng, Luo Pengli
Department of Nephrology, Affiliated Hospital of Qinghai University, Xining, 810000, People's Republic of China.
Clinical Research Center for Chronic Kidney Disease in Qinghai Province, Xining, 810000, People's Republic of China.
J Inflamm Res. 2025 May 28;18:6865-6875. doi: 10.2147/JIR.S524046. eCollection 2025.
Our study aims to investigate specific changes in serological 5-MTP expression in sepsis-associated acute kidney injury (SA-AKI) patients and assess its potential as a biomarker for SA-AKI occurrence. Additionally, we seek to evaluate the predictive value of 5-MTP in long-term clinical prognosis following SA-AKI.
A prospective cohort study included 31 healthy controls and 78 patients diagnosed with sepsis at the Affiliated Hospital of Qinghai University. Following the collection of serological samples, 5-MTP levels were determined using targeted metabolomics.Additionally, we collected clinical data, including blood routine, biochemical, inflammatory indicators and severity of disease. Spearman correlation, COX regression analysis and Kaplan-Meier curves were used to evaluate the correlation between serum 5-MTP and renal function and the value of prognosis.
The findings revealed that serum 5-MTP levels were significantly elevated in SA-AKI patients compared to both the healthy control and sepsis groups(<0.05), and were associated with Scr, BUN, and eGFR levels(<0.05). Additionally, 5-MTP was identified as an independent influencing factor for all-cause mortality in patients with sepsis and SA-AKI. Higher levels of 5-MTP were linked to faster recovery of kidney function, while lower levels were associated with increased 90-day all-cause mortality in SA-AKI patients.
5-MTP may have a protective role in the development of SA-AKI, and an early increase in serological expression of 5-MTP could positively impact the prognosis of sepsis and SA-AKI.
本研究旨在调查脓毒症相关急性肾损伤（SA-AKI）患者血清5-MTP表达的具体变化，并评估其作为SA-AKI发生生物标志物的潜力。此外，我们试图评估5-MTP对SA-AKI后长期临床预后的预测价值。
一项前瞻性队列研究纳入了青海大学附属医院的31名健康对照者和78名诊断为脓毒症的患者。采集血清样本后，采用靶向代谢组学方法测定5-MTP水平。此外，我们收集了临床数据，包括血常规、生化指标、炎症指标和疾病严重程度。采用Spearman相关性分析、COX回归分析和Kaplan-Meier曲线评估血清5-MTP与肾功能之间的相关性以及预后价值。
研究结果显示，与健康对照组和脓毒症组相比，SA-AKI患者的血清5-MTP水平显著升高（<0.05），且与Scr、BUN和eGFR水平相关（<0.05）。此外，5-MTP被确定为脓毒症和SA-AKI患者全因死亡率的独立影响因素。5-MTP水平较高与肾功能恢复较快相关，而水平较低与SA-AKI患者90天全因死亡率增加相关。
5-MTP可能在SA-AKI的发生发展中起保护作用，血清5-MTP表达的早期升高可能对脓毒症和SA-AKI的预后产生积极影响。
