运动神经元病中的感觉受累：自动热阈值测定的进一步证据。
Sensory involvement in motor neuron disease: further evidence from automated thermal threshold determination.
作者信息
Jamal G A, Weir A I, Hansen S, Ballantyne J P
出版信息
J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):906-10. doi: 10.1136/jnnp.48.9.906.
Abstract
Thermal thresholds were determined in 40 patients with motor neuron disease and in 40 age- and sex-matched healthy subjects. The thermal thresholds were estimated on the skin of wrist and ankle using an automated microprocessor controlled system and the "two alternative forced-choice method" of psycholphysical analysis. Abnormalities of thermal thresholds (greater than or equal to 99th percentile) were seen in 80% of the motor neuron disease patients. The results are in agreement with reports of sensory pathway involvement in the literature. Thermal threshold abnormalities are common in motor neuron disease and indicate the involvement of the small fibre afferent pathways.
摘要
对40例运动神经元病患者以及40例年龄和性别匹配的健康受试者测定了热阈值。使用自动微处理器控制系统和心理物理学分析的“二项必选法”在手腕和脚踝皮肤处估计热阈值。80%的运动神经元病患者出现热阈值异常（大于或等于第99百分位数）。结果与文献中关于感觉通路受累的报道一致。热阈值异常在运动神经元病中很常见，表明小纤维传入通路受累。
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本文引用的文献
1
Amyotrophic lateral sclerosis.
J Nerv Ment Dis. 1950 Jan;111(1):1-18. doi: 10.1097/00005053-195011110-00001.
2
Progressive motor neuron disease in adults; a clinical study with special reference to the course of the disease.
Acta Psychiatr Neurol Scand. 1952;27(1-2):137-56. doi: 10.1111/j.1600-0447.1952.tb04647.x.
3
SENSORY NERVE CONDUCTION IN AMYOTROPHIC LATERAL SCLEROSIS.
Neurology. 1964 Jan;14:31-3. doi: 10.1212/wnl.14.1.31.
4
Electrodiagnosis in motor neurone disease.
Proc R Soc Med. 1962 Dec;55:1024-8.
5
An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?
Brain. 1959 Jun;82:203-20. doi: 10.1093/brain/82.2.203.
6
Amyotrophic lateral sclerosis.
AMA Arch Neurol Psychiatry. 1953 Feb;69(2):171-92. doi: 10.1001/archneurpsyc.1953.02320260029002.
7
Morphometric comparison of the vulnerability of peripheral motor and sensory neurons in amyotrophic lateral sclerosis.
J Neuropathol Exp Neurol. 1981 Nov;40(6):667-75. doi: 10.1097/00005072-198111000-00008.
8
Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders: a review.
Brain. 1981 Jun;104(2):217-47. doi: 10.1093/brain/104.2.217.
9
Chronic pain syndrome in amyotrophic lateral sclerosis.
Arch Neurol. 1983 Jul;40(7):453-4. doi: 10.1001/archneur.1983.04050070083025.
10
Motor neuron disease (ALS): evaluation of detection thresholds of cutaneous sensation.
Neurology. 1983 Dec;33(12):1625-7. doi: 10.1212/wnl.33.12.1625.
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