Jamal G A, Weir A I, Hansen S, Ballantyne J P
J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):906-10. doi: 10.1136/jnnp.48.9.906.
Thermal thresholds were determined in 40 patients with motor neuron disease and in 40 age- and sex-matched healthy subjects. The thermal thresholds were estimated on the skin of wrist and ankle using an automated microprocessor controlled system and the "two alternative forced-choice method" of psycholphysical analysis. Abnormalities of thermal thresholds (greater than or equal to 99th percentile) were seen in 80% of the motor neuron disease patients. The results are in agreement with reports of sensory pathway involvement in the literature. Thermal threshold abnormalities are common in motor neuron disease and indicate the involvement of the small fibre afferent pathways.
对40例运动神经元病患者以及40例年龄和性别匹配的健康受试者测定了热阈值。使用自动微处理器控制系统和心理物理学分析的“二项必选法”在手腕和脚踝皮肤处估计热阈值。80%的运动神经元病患者出现热阈值异常（大于或等于第99百分位数）。结果与文献中关于感觉通路受累的报道一致。热阈值异常在运动神经元病中很常见，表明小纤维传入通路受累。
