Chen Zuhan, Bi Huanjing, Ding Xiaoming
Department of Kidney Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Mechanobiol Med. 2023 Oct 31;2(1):100028. doi: 10.1016/j.mbm.2023.100028. eCollection 2024 Mar.
The implantation of foreign materials often leads to fibroblast activation and fibrous capsule formation. The process of fibroblast-to-myofibroblast transition (FMT) is partially influenced by the surface properties of biomaterials, including factors such as stiffness, wettability, roughness, and topography. This article reviews the studies that concentrate on the connection between the topographical cues of biomaterials and FMT. We have summarized the key findings and subsequently analyzed the potential reasons behind the contradictory conclusions in these studies.
外来材料的植入通常会导致成纤维细胞活化和纤维囊形成。成纤维细胞向肌成纤维细胞转变（FMT）的过程部分受生物材料表面特性的影响，包括硬度、润湿性、粗糙度和拓扑结构等因素。本文综述了专注于生物材料拓扑线索与FMT之间联系的研究。我们总结了关键发现，随后分析了这些研究中相互矛盾结论背后的潜在原因。
