研究通讯：粪便免疫化学检测呈阳性患者的结直肠癌呼气检测：一项具有外部验证的多中心前瞻性横断面研究
Research Communication: Breath Testing for Colorectal Cancer Detection in Patients With a Positive Fecal Immunochemical Test: A Multicentre Prospective Cross-Sectional Study With External Validation.
作者信息
van Riswijk Milou L M, van Keulen Kelly E, Tan Adriaan C I T L, Schrauwen Ruud W M, de Vos Tot Nederveen Cappel Wouter H, Siersema Peter D
机构信息
Department of Gastroenterology and Hepatology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Dept. of Gastroenterology and Hepatology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands.
出版信息
Aliment Pharmacol Ther. 2025 Jul;62(2):208-213. doi: 10.1111/apt.70207. Epub 2025 Jun 3.
Colorectal cancer (CRC) screening using fecal immunochemical tests (FIT) is suboptimal. This multicentre study evaluated an electronic nose (e-nose) for CRC detection in FIT-positive patients, along with reproducibility and external validation. Among 3469 participants (40.1% female, median age 64.3y), CRC was diagnosed in 5.0%; 25.1% had a normal colonoscopy. The e-nose showed poor diagnostic performance (AUC 0.542; sensitivity 39.5%; specificity 68.3%) and low reproducibility (ICC 0.22). Despite high patient acceptability (95.3% willingness-to-repeat), these findings suggest e-nose technology is not yet ready for clinical implementation. Further research is needed to standardise and validate e-nose devices before supplementing current screening methods. Clinicaltrials.gov Identifier NCT03346005 and NCT04357158.
使用粪便免疫化学检测（FIT）进行结直肠癌（CRC）筛查并不理想。这项多中心研究评估了一种电子鼻（e-nose）在FIT阳性患者中检测CRC的情况，以及其可重复性和外部验证。在3469名参与者中（女性占40.1%，中位年龄64.3岁），5.0%被诊断为CRC；25.1%的人结肠镜检查正常。电子鼻的诊断性能较差（AUC为0.542；灵敏度为39.5%；特异性为68.3%）且可重复性较低（ICC为0.22）。尽管患者接受度较高（95.3%愿意再次使用），但这些结果表明电子鼻技术尚未准备好用于临床应用。在补充当前筛查方法之前，需要进一步研究来规范和验证电子鼻设备。Clinicaltrials.gov标识符：NCT03346005和NCT04357158。
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