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J Gen Physiol. 2025 Jul 7;157(4). doi: 10.1085/jgp.202413683. Epub 2025 Jun 3.
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本文引用的文献

1
Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology.电压门控钠离子和钙离子通道:发现、结构、功能和药理学。
Channels (Austin). 2023 Dec;17(1):2281714. doi: 10.1080/19336950.2023.2281714. Epub 2023 Nov 20.
2
A mechanistic reinterpretation of fast inactivation in voltage-gated Na channels.一种对电压门控钠离子通道快速失活的机制重新阐释。
Nat Commun. 2023 Aug 21;14(1):5072. doi: 10.1038/s41467-023-40514-4.
3
Structure of human Na1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome.人类Na1.5的结构揭示了与快速失活相关的片段是长QT综合征的一个突变热点。
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11). doi: 10.1073/pnas.2100069118.
4
Uncoupling sodium channel dimers restores the phenotype of a pain-linked Na 1.7 channel mutation.去偶联钠离子通道二聚体可恢复与疼痛相关的 Na 1.7 通道突变的表型。
Br J Pharmacol. 2020 Oct;177(19):4481-4496. doi: 10.1111/bph.15196. Epub 2020 Aug 24.
5
Mechanisms of sodium channel inactivation.钠通道失活的机制。
Curr Opin Neurobiol. 2003 Jun;13(3):284-90. doi: 10.1016/s0959-4388(03)00065-5.
6
The molecular basis of neuronal excitability.神经元兴奋性的分子基础。
Science. 1984 Feb 17;223(4637):653-61. doi: 10.1126/science.6320365.
7
Inactivation of the sodium channel. II. Gating current experiments.钠通道的失活。II. 门控电流实验。
J Gen Physiol. 1977 Nov;70(5):567-90. doi: 10.1085/jgp.70.5.567.

运用隐喻思维助力钠通道快速失活机制的研究。

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism.

作者信息

Hull Peter, Lampert Angelika

机构信息

Department of English for Academic and Special Purposes, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Institute of Neurophysiology, Uniklinik RWTH Aachen University , Aachen, Germany.

出版信息

J Gen Physiol. 2025 Jul 7;157(4). doi: 10.1085/jgp.202413683. Epub 2025 Jun 3.

DOI:10.1085/jgp.202413683
PMID:40459728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12132071/
Abstract

Metaphorical language is ubiquitous throughout the life sciences, with, for example, molecules forming chains which define genetic blueprints for the development of cells and ultimately the gates in the channels forming the subject of this special issue. Indeed, metaphor is a fundamental component of scientific discourse and influences how science is both communicated and understood across all levels of expertise. This article, written for readers without a background in linguistics, first provides a brief introduction to the mechanisms of scientific metaphor and then illustrates its productive application to the sodium channel fast inactivation mechanism.

摘要

隐喻性语言在整个生命科学领域无处不在,例如,分子形成链条,这些链条定义了细胞发育的基因蓝图,最终形成了本期特刊主题的通道中的门控机制。事实上,隐喻是科学话语的一个基本组成部分,影响着科学在各个专业层面的交流和理解方式。本文是为没有语言学背景的读者撰写的,首先简要介绍了科学隐喻的机制,然后说明了其在钠通道快速失活机制中的有效应用。