Balakin V E, Strelnikova N S, Rozanova O M, Smirnova E N, Belyakova T A, Shemyakov A E
Physical-Technical Center of Lebedev Physical Institute, Russian Academy of Sciences, Protvino, Russia.
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
Dokl Biochem Biophys. 2025 Jun;522(1):302-308. doi: 10.1134/S1607672925600356. Epub 2025 Jun 2.
The regularities of tumor induction and growth were studied in mice after a single ex vivo irradiation with a helium ion beam of Ehrlich adenocarcinoma ascites cells (EAC) at doses of 10 and 20 Gy in two positions of the Bragg curve (before the peak and at the peak) in comparison with X-ray radiation at the same doses. It was shown that the frequency of induction and delay in tumor appearance depend on the dose of helium ion irradiation. The following parameters were determined: the time of a fivefold increase in the EAC volume, tumor growth inhibition, tumor growth index (TGI), and lifetime increase (LTI) in mice. A decrease in the TGI values and an increase in the LTI values occurred with increasing dose for all types of radiation. The relative biological effectiveness (RBE) value for helium ions determined by the area under the EAC growth dynamics curves reached a maximum value of 1.8 upon irradiation at the Bragg peak at a dose of 20 Gy.
研究了用剂量为10和20 Gy的氦离子束在布拉格曲线的两个位置（峰前和峰处）对艾氏腹水癌细胞（EAC）进行单次体外照射后，小鼠体内肿瘤诱导和生长的规律，并与相同剂量的X射线辐射进行了比较。结果表明，肿瘤诱导频率和出现延迟取决于氦离子照射剂量。测定了以下参数：EAC体积增加五倍的时间、肿瘤生长抑制、肿瘤生长指数（TGI）和小鼠寿命增加（LTI）。对于所有类型的辐射，随着剂量增加，TGI值降低，LTI值增加。通过EAC生长动力学曲线下面积确定的氦离子相对生物效应（RBE）值在20 Gy剂量的布拉格峰处照射时达到最大值1.8。
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