埃塞俄比亚癫痫患者的健康相关生活质量及其预测因素：系统评价与荟萃分析。
Health-related quality of life and its predictors among epilepsy patients in Ethiopia: Systematic review and meta-analysis.
作者信息
Mekonnen Chilot Kassa, Abate Hailemichael Kindie, Azagew Abere Woretaw, Agimas Muluken Chanie
机构信息
Department of Medical Nursing, School of Nursing, University of Gondar, Gondar, Ethiopia.
Department of Epidemiology and Biostatics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.
出版信息
PLoS One. 2025 Jun 3;20(6):e0324363. doi: 10.1371/journal.pone.0324363. eCollection 2025.
INTRODUCTION
Epilepsy is a common non-communicable neurological disorder associated with recurrent seeding of cerebral neurons or brain cells and episodes of unprovoked seizures with or without loss of consciousness. Although there are studies on the health-related quality of life of epilepsy patients in Ethiopia, there are remarkable variations in the estimates of health-related quality of life.
OBJECTIVES
This systematic review and meta-analysis aimed to determine the pooled effect size of the health-related quality of life of adult epilepsy patients in Ethiopia.
METHODS
Original articles about the health-related quality of life among epilepsy patients in Ethiopia were searched through known and international databases (PubMed, Scopus, and Web of Science) and search engines (Google and Google Scholar). Data were extracted using a standard data extraction checklist developed according to Joanna Briggs Institute (JBI). The I2 statistics were used to identify heterogeneity across studies. Funnel plot asymmetry and Egger's tests were used to check for publication bias. The STATA version 11 software was employed for statistical analysis to pool the mean scores of health-related quality-of-life.
RESULT
A total of 16 cross-sectional studies with a sample size of 5294 took part. The pooled overall mean score of health-related quality of life among epilepsy patients in Ethiopia was 52.82 ± 13.24 [95%CI (46.41, 59.21)], I2 = 100%, p-value <0.001. Besides, the overall pooled mean score of health-related quality of life based on the measuring tools WHO-QOL-BREF, QOLIE-31, and QOLIE-10 was 51.50 ± 11.32 (49.11, 53.90), 59.99 ± 12.67 (52.22, 67.77), and 44.33 ± 21.23 (13.09, 75.57) respectively.
CONCLUSION
The least overall pooled mean score of HRQOL was the QOLIE-10 measuring tool epileptic patients' mean score compared to other health-related quality-of-life measuring tools such as WHOQOL-BREF, and QOLIE-31. Moreover, the least overall pooled mean score of HRQOL using the WHOQOL-BREF was the environmental domain followed by the emotional domain, as compared to all other domains in each measuring tool of health-related quality of life.
引言
癫痫是一种常见的非传染性神经系统疾病，与大脑神经元或脑细胞的反复异常放电以及无端发作（伴有或不伴有意识丧失）有关。尽管埃塞俄比亚有关于癫痫患者健康相关生活质量的研究，但在健康相关生活质量的评估方面存在显著差异。
目的
本系统评价和荟萃分析旨在确定埃塞俄比亚成年癫痫患者健康相关生活质量的合并效应量。
方法
通过知名国际数据库（PubMed、Scopus和科学网）以及搜索引擎（谷歌和谷歌学术）检索关于埃塞俄比亚癫痫患者健康相关生活质量的原始文章。使用根据乔安娜·布里格斯研究所（JBI）制定的标准数据提取清单提取数据。I²统计量用于识别研究间的异质性。漏斗图不对称性和埃格检验用于检查发表偏倚。使用STATA 11版软件进行统计分析，以汇总健康相关生活质量的平均得分。
结果
共有16项横断面研究参与，样本量为5294。埃塞俄比亚癫痫患者健康相关生活质量的总体合并平均得分为52.82±13.24[95%置信区间（46.41，59.21）]，I² = 100%，p值<0.001。此外，基于测量工具WHO-QOL-BREF、QOLIE-31和QOLIE-10的健康相关生活质量总体合并平均得分分别为51.50±11.32（49.11，53.90）、59.99±12.67（52.22，67.77）和44.33±21.23（13.09，75.57）。
结论
与其他健康相关生活质量测量工具（如WHOQOL-BREF和QOLIE-31）相比，HRQOL总体合并平均得分最低的是QOLIE-10测量工具所测得的癫痫患者平均得分。此外，在每种健康相关生活质量测量工具的所有其他领域中，使用WHOQOL-BREF测得的HRQOL总体合并平均得分最低的是环境领域，其次是情感领域。
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