Nagahama F, Ito R, Sasaki Y, Ohashi R, Shimomura J, Sasaki N, Osaki Y, Yozawa K, Tamura T, Isobe H
Jpn J Antibiot. 1985 Jun;38(6):1533-51.
The efficacy, safety and utility of sisomicin (SISO) followed intravenous infusion were evaluated in 35 cases with various respiratory infections. For many cases, SISO was given at a daily dosage of 100 mg, and a single dose was infused over about 1 hour. Clinical efficacy was evaluable in 28 cases including pneumonia (14 cases), bronchitis (8 cases), bronchiectasis (4 cases), pulmonary suppuration (1 case) and pulmonary abscess plus pyothorax (1 case). Almost cases had diagnosis of serious infection associated with various diseases. Clinical efficacy was evaluated as "excellent" in 2 cases, "good" in 15 cases, "fair" in 5 cases and "poor" in 6 cases, and efficacy rate in total case was 60.7%. Efficacy rate stratified by disease was calculated as 57.1% in pneumonia, 87.5% in bronchitis, 50.0% in bronchiectasis. Responses against pulmonary suppuration or pulmonary abscess with pyothorax were little or not. Bacteriologically, organisms isolated from sputum cleared in 7 out of 15 evaluable cases, thus the responses rate was 46.7%. Adverse reaction probably due to treatment observed in 2 cases with hepatic dysfunction. Blood levels of SISO at the end of infusion were ranged from 2.1 to 6.4 micrograms/ml, and no tendency of accumulation in blood after repeated infusion was showed.
对35例各种呼吸道感染患者进行了静脉输注西索米星（SISO）的疗效、安全性和实用性评估。许多病例中，SISO的日剂量为100mg，单次剂量在约1小时内输注完毕。28例患者可评估临床疗效，包括肺炎（14例）、支气管炎（8例）、支气管扩张（4例）、肺脓肿（1例）以及肺脓肿合并脓胸（1例）。几乎所有病例都诊断为与各种疾病相关的严重感染。临床疗效评估为“优”2例，“良”15例，“中”5例，“差”6例，总有效率为60.7%。按疾病分层计算的有效率为肺炎57.1%，支气管炎87.5%，支气管扩张50.0%。对肺脓肿或肺脓肿合并脓胸的反应很少或没有。细菌学方面，15例可评估病例中有7例痰液中分离出的病原体清除，因此反应率为46.7%。观察到2例可能因治疗导致肝功能障碍的不良反应。输注结束时SISO的血药浓度范围为2.1至6.4微克/毫升，重复输注后未显示出血液中药物蓄积的趋势。
