Tamura K, Araki Y, Amamoto T, Seita M
Jpn J Antibiot. 1984 Jul;37(7):1237-40.
Sisomicin sulfate (SISO) was used for the treatment of infections complicated by malignant diseases in 10 cases; 4 cases with suspicious sepsis, 2 with pneumonia, 2 with urinary tract infection, 1 with renal abscess and 1 with cholecystitis. SISO was administered by intravenous drip infusion at daily dose from 100 to 150 mg for 6 to 12 days, concomitantly with other antibiotics. Clinical results were as follows; Good in 2, fair in 5, poor in 3 cases. As to the side effects of SISO, cylindruria with aggravation of microscopic hematuria and elevations of GOT, GPT and A1-P were observed each one of them, respectively. The relationship to the SISO, however, was not clear. In view of the above results, the drip infusion of SISO may be useful for the treatment of serious infection complicated by malignant diseases.
硫酸西索米星（SISO）用于治疗10例合并恶性疾病的感染；4例疑似败血症，2例肺炎，2例尿路感染，1例肾脓肿和1例胆囊炎。硫酸西索米星通过静脉滴注给药，每日剂量为100至150毫克，持续6至12天，同时使用其他抗生素。临床结果如下：2例良好，5例尚可，3例不佳。关于硫酸西索米星的副作用，分别观察到1例出现管型尿伴镜下血尿加重，以及谷草转氨酶（GOT）、谷丙转氨酶（GPT）和碱性磷酸酶（A1-P）升高。然而，它们与硫酸西索米星的关系尚不清楚。鉴于上述结果，静脉滴注硫酸西索米星可能对治疗合并恶性疾病的严重感染有用。
