Tamura K, Iwakiri R, Amamoto T, Seita M
Jpn J Antibiot. 1985 Jun;38(6):1552-6.
SISO in doses of 1.0 to 1.8 mg/kg was administered by a 30-minute intravenous infusion every 12 hours to 10 patients with infections, 9 of whom had underlying diseases including malignant diseases, diabetes mellitus, and diabetes insipidus with indwelling FOLEY catheter. The serum concentration of SISO was around 6.75 micrograms/ml in the end of infusion, and less than 1.0 micrograms/ml at 8 to 12 hours after infusion. SISO was given to the patients as a single agent for at least 3 to 5 days and all patients experienced an excellent to good response clinically, and causative organisms which showed a minimal inhibitory concentration of less than 1.56 micrograms/ml disappeared after the treatment associated with clinical improvement. There were no untoward effects noted in this study.
以1.0至1.8毫克/千克的剂量，每12小时通过30分钟静脉输注的方式，对10名感染患者施用了SISO，其中9名患者患有包括恶性疾病、糖尿病和伴有留置福勒氏导尿管的尿崩症等基础疾病。输注结束时，SISO的血清浓度约为6.75微克/毫升，输注后8至12小时低于1.0微克/毫升。SISO作为单一药物给予患者至少3至5天，所有患者临床上均有良好至优秀的反应，且最低抑菌浓度低于1.56微克/毫升的致病微生物在治疗后随着临床改善而消失。本研究未观察到不良影响。
